The Norwegian Mother and Child Study: Environmental Spec

挪威母婴研究是对挪威孕妇及其子女进行的一项队列研究。NIEHS正在为这一努力做出贡献，创建了一个生物标本库，以评估环境暴露和对孕妇及其未出生的孩子的健康影响。截至2004年8月31日，22,710名妇女为NIEHS研究部分提供了生物样本(血液和尿液)；本财年有10,000名妇女参加。这些样本已经在挪威各地的41家医院收集，包括城市中心和北极地区。招生目标是5万名女性。按照目前的招募速度，我们预计将有30,000名妇女在怀孕17周时采集血液和尿液样本，以评估环境暴露情况。 在上一财年，我们解决了与样品运输和搬运有关的问题。与疾控中心合作，我们确定了防止尿样细菌污染的最佳方法，同时仍保留了未来感兴趣的分析物(酚、邻苯二甲酸盐、非持久性农药、砷、汞)。这些数据将对大型队列研究中的其他研究人员有用，目前正在准备一份手稿。与挪威调查人员合作，我们正在实施一项质量保证实验和方案，以评估各种参数的储存条件。这将需要大约2年的时间才能完成。初步质量保证措施的结果将在2004年10月的一次专业会议上提出。我们目前正在设计一项研究，使用NIEHS样本并链接到母亲的问卷数据和医疗出生登记数据，以评估健康状况

The Norwegian Mother and Child study is a cohort study of pregnant women and their children in Norway. NIEHS is contributing to this effort by creating of a biological specimen repository to evaluate environmental exposures and health effects to pregnant women and their unborn children. As of Aug 31, 2004, 22,710 women had contributed biological samples (blood and urine) for the NIEHS portion of the study; 10,000 women were enrolled this fiscal year. These samples have been collected at 41 hospitals across Norway including urban centers and the Arctic regions. The enrollment target is 50,000 women. At the current recruitment rate we anticipate 30,000 women with blood and urine samples collected at 17 weeks gestation to evaluate for environmental exposures. During the past fiscal year, we resolved problems associated with sample shipment and handling. Working with CDC, we identified the optimal means to prevent bacterial contamination of urine samples while still maintaining the analytes of future interest (phenols, phthalates, non-persistent pesticides, arsenic, mercury). These data will be of use to other investigators in large cohort studies and a manuscript is in preparation. In collaboration with Norwegian investigators, we are implementing a quality assurance experiment and protocol to assess storage conditions for a variety of parameters. This will take ~2 years to complete. Results of the initial quality assurance measures will be presented at a professional meeting in October 2004. We are currently designing a study to use the NIEHS samples and link to the questionnaire data from the mother and the Medical Birth Registry data to assess health