Preventing infection to promote skin wound healing

预防感染促进皮肤伤口愈合

• 批准号: 2437309
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2437309
• 关键词: Preventing; infection; promote; skin; wound

Infection of skin wounds is a major barrier to healthy wound healing in the ageing population and in diabetes. These chronic skin wounds are susceptible to bacterial infection and in certain circumstances, the infection spreads and can result in lower limb amputation. Preventing infection of skin tissue of healing wounds is thus paramount. The project will develop and extend a human skin biopsy "wound healing" model recently established (within Norwich Skin Platform / https://www.uea.ac.uk/norwich-skin-platform/about) to mimic infection under disease conditions and to explore re-epithelialisation and resident immune cell responses to bacteria and products which may be beneficial to wound healing.

皮肤伤口感染是老龄人口和糖尿病患者伤口健康愈合的主要障碍。这些慢性皮肤伤口容易受到细菌感染，在某些情况下，感染会扩散，并可能导致下肢截肢。因此，防止愈合伤口的皮肤组织感染是至关重要的。该项目将开发和扩展最近建立的人体皮肤活检“伤口愈合”模型（在Norwich皮肤平台/ https://www.uea.ac.uk/norwich-skin-platform/about内），以模拟疾病条件下的感染，并探索可能有利于伤口愈合的细菌和产品的再上皮化和常驻免疫细胞反应。