Evolution and pathogenicity of NDM-1 positive Escherichia coli

NDM-1阳性大肠杆菌的进化和致病性

• 批准号: nhmrc : 1033799
• 负责人: A/Pr Scott Beatson
• 金额: $ 42.89万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/evolution-pathogenicity-ndm-escherichia-coli/110901
• 关键词: Evolution; pathogenicity; NDM; positive; Escherichia

Antibiotic resistance (AR), as highlighted by the WHO, is the most pressing medical need of the 21C – some infections are now untreatable. Our research will focus on the new "superbug" NDM-1 positive E. coli. We will correlate AR and pathogenicity and explore the evolution of these "superbugs" using state-of-the-art sequencing. This research will benefit Australian medicine by predicting timelines of AR epidemics and by conducting the first analyses on the virulence potential of these strains.

正如世卫组织强调的那样，抗生素耐药性(AR)是21世纪最紧迫的医疗需求--一些感染现在无法治愈。我们的研究将集中在新的超级细菌NDM-1阳性的大肠杆菌上。我们将把AR和致病性联系起来，并使用最先进的测序技术来探索这些“超级细菌”的进化。这项研究将通过预测AR流行的时间表和对这些菌株的毒力潜力进行首次分析，使澳大利亚医学界受益。