Bacterial Pathogenomics: whole-genome sequencing to investigate infection transmission, pathogenesis and antibiotic resistance

细菌病理基因组学：通过全基因组测序研究感染传播、发病机制和抗生素耐药性

• 批准号: nhmrc : 1090456
• 负责人: A/Pr Scott Beatson
• 金额: $ 31.74万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bacterial-pathogenomics-whole-antibiotic-resistance/519286
• 关键词: Bacterial; Pathogenomics; whole; genome; sequencing

As bacterial superbugs – resistant to multiple antibiotics – dominate the headlines, the pipeline for new antibiotics has all but dried up. High-throughput DNA sequencing heralds a golden opportunity for infectious disease research. By studying the entire collection of genes - the genome - of large numbers of multidrug resistant bacterial strains, we aim to better understand the genetic changes that govern the emergence and global spread of superbugs and translate these findings into the clinic.

随着细菌超级细菌--对多种抗生素具有耐药性--占据了新闻头条，新抗生素的管道几乎已经枯竭。高通量DNA测序预示着传染病研究的黄金机会。通过研究大量多重耐药菌株的整个基因集合-基因组，我们的目标是更好地了解控制超级细菌出现和全球传播的遗传变化，并将这些发现转化为临床。