Escherichia coli ST131: an emerging pathogen

大肠杆菌 ST131：一种新兴病原体

• 批准号: nhmrc : 1012076
• 负责人: A/Pr Scott Beatson
• 金额: $ 38.29万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/escherichia-coli-st131-emerging-pathogen/109633
• 关键词: Escherichia; coli; ST131; emerging; pathogen

Uropathogenic Escherichia coli (UPEC) are a major cause of urinary tract infections (UTI) and sepsis. Recently, a highly virulent clone of UPEC (E. coli ST131) that is resistant to multiple types of antibiotics has emerged worldwide. This project addresses the mechanisms by which E. coli ST131 can colonise the urinary tract and cause disease. The outcomes of this project will be a better understanding of how E. coli ST131 causes disease, and potentially new treatment regimes for UTI.

尿路致病性大肠杆菌（UPEC）是尿路感染（UTI）和败血症的主要原因。最近，一个强毒力的克隆UPEC（E。大肠杆菌ST 131）对多种抗生素具有耐药性。本项目探讨了E.大肠杆菌ST 131能在泌尿道定植并引起疾病。本项目的成果将是更好地了解如何E。大肠杆菌ST131引起的疾病，和潜在的新的治疗方案的UTI。