Escherichia coli ST131: an emerging pathogen

尿路致病性大肠杆菌（UPEC）是尿路感染（UTI）和败血症的主要原因。最近，在世界范围内出现了一种对多种抗生素具有耐药性的UPEC（大肠杆菌ST131）的高毒力克隆。该项目解决了大肠杆菌ST131可以在泌尿道定植并引起疾病的机制。该项目的结果将是更好地了解大肠杆菌ST131如何引起疾病，并可能为尿路感染提供新的治疗方案。

Uropathogenic Escherichia coli (UPEC) are a major cause of urinary tract infections (UTI) and sepsis. Recently, a highly virulent clone of UPEC (E. coli ST131) that is resistant to multiple types of antibiotics has emerged worldwide. This project addresses the mechanisms by which E. coli ST131 can colonise the urinary tract and cause disease. The outcomes of this project will be a better understanding of how E. coli ST131 causes disease, and potentially new treatment regimes for UTI.