Pathogenomics: new ways to exploit genome sequence data from pathogenic bacteria.

病理基因组学：利用病原菌基因组序列数据的新方法。

• 批准号: nhmrc : 511224
• 负责人: A/Pr Scott Beatson
• 金额: $ 36.5万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pathogenomics-new-ways-pathogenic-bacteria/98577
• 关键词: Pathogenomics; new; ways; exploit; genome

Bacterial pathogens are locked in an evolutionary battle of survival with their eukaryote hosts. The rapidly evolving genes of medically-important pathogens are generally those required for adaptation to the human host. This project aims to exploit the abundance of available bacterial genome sequences to predict rapid evolution in bacterial pathogens using computational methods. The protein products of such genes offer novel targets for therapeutic intervention.

细菌病原体被锁定在与真核生物宿主的生存进化之战中。医学上重要的病原体的快速进化基因通常是适应人类宿主所需的基因。本项目旨在利用丰富的细菌基因组序列，利用计算方法预测细菌病原体的快速进化。这些基因的蛋白质产物为治疗干预提供了新的靶点。