Functional and genomic analysis of E. coli that cause urinary tract infection

引起尿路感染的大肠杆菌的功能和基因组分析

• 批准号: nhmrc : GNT1067455
• 负责人: A/Pr Scott Beatson
• 金额: $ 79.31万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-genomic-analysis-tract-infection/1344936
• 关键词: Functional; genomic; analysis; E.; coli

Uropathogenic Escherichia coli (UPEC) is a major cause of urinary tract infections (UTI) and sepsis. Recently, a highly virulent clone of UPEC (E. coli ST131) that is resistant to multiple types of antibiotics has emerged and spread worldwide. This project uses genomic and high-throughput functional analysis methods to understand E. coli ST131 virulence and resistance. The outcomes of the work will be a better understanding of how E. coli ST131 causes disease, and potentially new treatment regimes for UTI.

尿路致病性大肠杆菌（UPEC）是尿路感染（UTI）和败血症的主要原因。最近，一个强毒力的克隆UPEC（E。大肠杆菌ST 131）对多种类型的抗生素具有耐药性，已经出现并在世界范围内传播。本项目采用基因组学和高通量功能分析方法来了解E. coli ST 131毒力和抗性。这项工作的成果将是更好地了解E。大肠杆菌ST131引起的疾病，和潜在的新的治疗方案的UTI。