Adiposity, BP & the inflammatory response to sleep loss

描述(由申请人提供)： 最近的研究表明，炎症介质，有助于预测健康的无症状个体发生心血管疾病的风险，也因实验性睡眠剥夺而增加。炎症标志物的低基础水平也可见于“代谢综合征”，我们推测睡眠不足或睡眠不足可能是代谢综合征发生的关键因素。我们将通过阻断已知在睡眠剥夺期间随之而来的血压升高来检验这一假设，即炎症的基础变化实际上是次要于与切应力相关的心血管因素。我们预计，阻止睡眠剥夺导致的血压升高将防止炎症标志物的上升。我们还将测试这一假设，即中等脂肪的人遭受急性睡眠剥夺的炎症和自主神经后果的风险更大。在这项研究的筛选数据中，我们还将调查肥胖、心血管健康、C反应蛋白和习惯性睡眠时间和质量之间的关系。

DESCRIPTION (provided by applicant): Recent studies have shown that mediators of inflammation, useful in predicting risk of developing cardiovascular disease in healthy asymptomatic individuals, are also increased by experimental sleep deprivation. Low basal increases in inflammatory markers are also seen in "metabolic syndrome" and we hypothesize that inadequate or insufficient sleep may be a pivotal contributing factor in the development of metabolic syndrome. We will test the hypothesis that basal changes in inflammation are actually secondary to cardiovacular factors associated with shear stress, by blocking the increase of blood pressure that is known to ensue during sleep deprivation. We expect that blocking the sleep deprivation associated increase in blood pressure will prevent the rise of inflammatory markers. We will also test the hypothesis that moderately adipose individuals are at greater risk to suffer the inflammatory and autonomic consequences of acute sleep deprivation. In screening data from this study we will also investigate the relationship between adiposity, cardiovascular fitness, C-reactive protein and habitual sleep duration and quality.