Aging & the inflammatory, metabolic and autonomic response to sleep loss

描述（由申请人提供）：衰老的条件包括炎症增加，心血管疾病、糖尿病和其他几种与炎症相关的疾病（如关节炎、骨质疏松症和阿尔茨海默病）的风险增加。预防这些疾病发展的因素，包括运动、饮食和充足的睡眠，在衰老过程中也可能更难控制。越来越多的证据表明，心血管健康、健康的饮食和充足的睡眠在预防炎症方面有很高的回报。睡眠时间随着年龄的增长而减少，65岁以上的人群中有三分之二的人声称每周至少经历一次睡眠问题。在夜间健康睡眠时，血液循环中的内皮标记物减少，血压降至一天中的最低水平。累积部分睡眠剥夺和急性完全睡眠剥夺的对照实验研究表明，炎症系统在睡眠剥夺期间被激活，白细胞（wbc）、白细胞介素-6 （IL-6）和c反应蛋白（CRP）增加。睡眠缺失期间炎症系统激活的机制尚不清楚，但我们假设与衰老相关的代谢和自主系统变化有关。我们将通过对这些系统进行64小时的守夜来测试这一点，将这些系统的反应与正常睡眠对比控制条件进行比较，我们将调查年轻人和老年人，肥胖和瘦弱个体之间的差异。另一项代谢挑战包括在基线和守夜后期进行的空腹口服葡萄糖测试。

DESCRIPTION (provided by applicant): Conditions of aging include increased inflammation and increased risk for cardiovascular disease, diabetes and several other diseases linked to inflammation such as arthritis, osteoporosis and Alzheimer's disease. Factors that protect against development of these diseases, including exercise, diet and adequate sleep may also be more difficult to control over the course of the aging process. Evidence is mounting, which suggests that cardiovascular fitness, healthy diet and adequate sleep bring high returns in the prevention of inflammation. Sleep duration decreases with aging and two thirds of the population over 65 years of age claim to experience sleep problems at least once a week. At night during healthy sleep, endothelial markers decrease in circulation and blood pressure drops to its diurnal low. Controlled experimental studies of cumulative partial and acute total sleep deprivation have shown that inflammatory systems are activated during sleep loss and that white blood cells (WBCs), interleukin-6 (IL-6) and C-reactive protein (CRP) increase. The mechanism(s) for this activation of the inflammatory system during sleep loss are not known, but we hypothesize that metabolic and autonomic system changes related to aging are involved. We will test this by challenging these systems with a 64 hour vigil, comparing the responses in these systems to normal sleep contrast control conditions, and we will investigate differences between young and elderly, adipose and lean individuals. An additional metabolic challenge includes the fasting oral glucose test conducted at baseline and during the latter part of the vigil.