Aging & the inflammatory, metabolic and autonomic response to sleep loss

老化

基本信息

批准号：
7647136
负责人：
JANET M MULLINGTON
金额：
$ 29.85万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-08-01 至 2011-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7647136
关键词：
Acute Acute-Phase Reaction Adipocytes Adipose tissue Age Age-Years Aging Aging-Related Process Alzheimer&apos s Disease American Arthritis Attention Autonomic nervous system Blood Pressure C-reactive protein Cardiovascular system Chronic Clinical Control Groups Controlled Study Coronary heart disease Data Development Diabetes Mellitus Diet Habits Disease Drops Elderly Endocrine Endothelial Cells Fasting Foundations Future Gastroesophageal reflux disease Glucose Half-Life Health Hepatic Homeostasis Hour Human Hygiene Individual Individual Differences Inflammation Inflammation Mediators Inflammatory Interleukin-6 Lead Leukocytes Link Maintenance Medical Metabolic Modeling OGTT Obesity Oral Osteoporosis Parkinson Disease Persons Physiological Plasma Proteins Play Population Prevalence Prevention Proteins Protocols documentation Research Personnel Resistance Risk Role Services Sleep Sleep Apnea Syndromes Sleep Deprivation Sleep Disorders Sleep disturbances Sleeplessness Social Security Societies Stimulus Surveys System Testing Time aged aging population cardiovascular disorder risk cardiovascular risk factor diet and exercise disorder prevention experience fitness good diet impression neurobehavioral peripheral blood research study response

项目摘要

DESCRIPTION (provided by applicant): Conditions of aging include increased inflammation and increased risk for cardiovascular disease, diabetes and several other diseases linked to inflammation such as arthritis, osteoporosis and Alzheimer's disease. Factors that protect against development of these diseases, including exercise, diet and adequate sleep may also be more difficult to control over the course of the aging process. Evidence is mounting, which suggests that cardiovascular fitness, healthy diet and adequate sleep bring high returns in the prevention of inflammation. Sleep duration decreases with aging and two thirds of the population over 65 years of age claim to experience sleep problems at least once a week. At night during healthy sleep, endothelial markers decrease in circulation and blood pressure drops to its diurnal low. Controlled experimental studies of cumulative partial and acute total sleep deprivation have shown that inflammatory systems are activated during sleep loss and that white blood cells (WBCs), interleukin-6 (IL-6) and C-reactive protein (CRP) increase. The mechanism(s) for this activation of the inflammatory system during sleep loss are not known, but we hypothesize that metabolic and autonomic system changes related to aging are involved. We will test this by challenging these systems with a 64 hour vigil, comparing the responses in these systems to normal sleep contrast control conditions, and we will investigate differences between young and elderly, adipose and lean individuals. An additional metabolic challenge includes the fasting oral glucose test conducted at baseline and during the latter part of the vigil.

描述（由申请人提供）：衰老的状况包括增加炎症和心血管疾病，糖尿病和其他几种与炎症有关的疾病，例如关节炎，骨质疏松症和阿尔茨海默氏病。防止这些疾病发展的因素，包括运动，饮食和足够的睡眠，也可能更难控制衰老过程。有证据表明，这表明心血管健身，健康的饮食和足够的睡眠在预防炎症方面带来了很高的回报。随着衰老和65岁以上人口的三分之二，睡眠持续时间至少每周遇到睡眠问题。在健康睡眠期间，内皮标记物的循环量降低，血压降低到昼夜降低。对累积部分和急性总睡眠剥夺的对照实验研究表明，炎症系统在睡眠丧失期间被激活，白细胞（WBC），白介素6（IL-6）（IL-6）和C反应蛋白（CRP）增加。尚不清楚这种激活在睡眠损失期间激活这种激活的机制，但我们假设涉及与衰老有关的代谢和自主系统变化。我们将通过64小时的守夜来挑战这些系统，将这些系统中的响应与正常睡眠对比度控制条件进行比较，我们将研究年轻人和老年人，脂肪和瘦人的差异。另一个代谢挑战包括在基线和守夜后期进行的空腹口服葡萄糖测试。