Repeated challenge of insufficient sleep: Effects on endothelial function

描述(由申请人提供)：一天24小时，一周7天的工作世界在我们有生之年来到了这里，并将继续存在。美国人的工作越来越多，经常同时从事多份工作。一周中睡眠时间较短，然后在周末尝试恢复的模式是常见的做法，但我们对相关的健康风险知之甚少。在增加心血管疾病的已知危险标记物、反复睡眠不足的夜晚方面的成本是多少，这种成本是否与重复、没有充分恢复的成本相加？越来越多的证据表明，睡眠时间短与新陈代谢和炎症相关疾病的发展有关，如心血管疾病。心血管疾病的发生机制包括血管功能受损和炎症。目前的应用旨在研究在4个周期(每个周期包括3个晚上，每晚4小时的睡眠机会)中重复短夜间睡眠持续时间的效果，以及每个短睡眠周期随后是单个晚上的恢复睡眠。血管反应性将使用肱动脉血流介导的扩张技术进行评估，微循环血管扩张将使用灌注成像技术进行评估。此外，还将研究外周循环中测定的IL-6和sVCAM-1与血管功能的相关性。

DESCRIPTION (provided by applicant): The 24-hour-a-day, 7-day a week, work-world arrived within our lifetimes, and is here to stay. Americans are working more and more, frequently at multiple jobs. The pattern of short sleep during the week followed by attempts to recover on the weekend is in common practice, but we know little of the associated health risks. What is the cost in terms of increasing known risk markers for cardiovascular disease, of repeated nights of insufficient sleep, and is this cost compounded with repetition, without adequate recovery? Evidence is accumulating to suggest that short sleep duration is linked to the development of metabolic and inflammation-associated diseases, such as cardiovascular disease. Mechanisms involved in the development of cardiovascular disease include impaired vascular function and inflammation. The current application is designed to investigate the effects of repeated periods of short nocturnal sleep duration in 4 cycles (each cycle consisting of 3 nights of 4 hours of sleep opportunity per night), and each cycle of short sleep followed by a single night of recovery sleep. Vascular reactivity will be assessed using brachial artery flow mediated dilation, and microcirculatory vasodilation will be assessed using perfusion imaging techniques. The dependence of IL-6 and sVCAM-1 as measured in peripheral circulation, on vascular function, will also be investigated.