Repeated challenge of insufficient sleep: Effects on endothelial function

描述（由申请人提供）：一天24小时，一周7天，工作世界在我们的有生之年到来，并将继续存在。美国人的工作越来越多，经常做多份工作。工作日睡眠不足，然后在周末试图恢复的模式是一种常见的做法，但我们对相关的健康风险知之甚少。就增加已知心血管疾病风险指标而言，反复睡眠不足的代价是什么？这种代价是否与重复而没有充分恢复相结合？越来越多的证据表明，睡眠时间短与代谢和炎症相关疾病（如心血管疾病）的发展有关。心血管疾病发生的机制包括血管功能受损和炎症。目前的应用程序旨在调查四个周期（每个周期由每晚4小时睡眠机会的3个晚上组成）中反复出现的夜间短睡眠时间的影响，每个短睡眠周期之后是一个晚上的恢复睡眠。血管反应性将通过肱动脉血流介导的扩张来评估，微循环血管扩张将通过灌注成像技术来评估。外周循环中IL-6和sVCAM-1对血管功能的依赖性也将被研究。

DESCRIPTION (provided by applicant): The 24-hour-a-day, 7-day a week, work-world arrived within our lifetimes, and is here to stay. Americans are working more and more, frequently at multiple jobs. The pattern of short sleep during the week followed by attempts to recover on the weekend is in common practice, but we know little of the associated health risks. What is the cost in terms of increasing known risk markers for cardiovascular disease, of repeated nights of insufficient sleep, and is this cost compounded with repetition, without adequate recovery? Evidence is accumulating to suggest that short sleep duration is linked to the development of metabolic and inflammation-associated diseases, such as cardiovascular disease. Mechanisms involved in the development of cardiovascular disease include impaired vascular function and inflammation. The current application is designed to investigate the effects of repeated periods of short nocturnal sleep duration in 4 cycles (each cycle consisting of 3 nights of 4 hours of sleep opportunity per night), and each cycle of short sleep followed by a single night of recovery sleep. Vascular reactivity will be assessed using brachial artery flow mediated dilation, and microcirculatory vasodilation will be assessed using perfusion imaging techniques. The dependence of IL-6 and sVCAM-1 as measured in peripheral circulation, on vascular function, will also be investigated.