ADIPOSITY, BP, AND THE INFLAMMATORY RESPONSE TO SLEEP LOSS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 最近的研究表明，炎症介质，有助于预测健康的无症状个体发生心血管疾病的风险，也因实验性睡眠剥夺而增加。炎症标志物的低基础水平也会出现在“代谢综合征”中，研究人员推测，睡眠不足或睡眠不足可能是代谢综合征发生的关键因素。研究人员使用了一项安慰剂对照研究，假设炎症的基础变化实际上是与切应力相关的心血管因素的次要因素。在这项研究中，已知在睡眠剥夺期间随之而来的血压升高是通过使用β受体阻滞剂来实验钳制的。他们预计，阻止睡眠不足导致的血压上升将阻止炎症标志物的上升。他们还将检验这一假设，即中等脂肪的人遭受急性睡眠剥夺的炎症和自主神经后果的风险更大。在这项研究的筛选数据中，将考察肥胖、心血管健康、C反应蛋白和习惯性睡眠时间和质量之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent studies have shown that mediators of inflammation, useful in predicting risk of developing cardiovascular disease in healthy asymptomatic individuals, are also increased by experimental sleep deprivation. Low basal increases in inflammatory markers are also seen in "metabolic syndrome" and the researchers hypothesize that inadequate or insufficient sleep may be a pivotal contributing factor in the development of metabolic syndrome. The researchers hypothesize that basal changes in inflammation are actually secondary to cardiovascular factors associated with shear stress, using a placebo controlled study where the increase of blood pressure that is known to ensue during sleep deprivation is experimentally clamped, through the use of a beta blocker. They expect that blocking sleep deprivation associated increase in blood pressure will prevent the rise of inflammatory markers. They will also test the hypothesis that moderately adipose individuals are at greater risk to suffer the inflammatory and autonomic consequences of acute sleep deprivation. In screening date from this study, the relationship between adiposity, cardiovascular fitness, C-reactive protein, and habitual sleep duration and quality will be looked at.