ADIPOSITY, BP, AND THE INFLAMMATORY RESPONSE TO SLEEP LOSS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 最近的研究表明，炎症介质，用于预测健康无症状个体发生心血管疾病的风险，也增加了实验性睡眠剥夺。炎症标志物的低基础增加也见于“代谢综合征”，研究人员假设睡眠不足或不足可能是代谢综合征发展的关键因素。研究人员假设，炎症的基础变化实际上是继发于与剪切应力相关的心血管因素，使用安慰剂对照研究，其中已知在睡眠剥夺期间随之发生的血压升高通过使用β受体阻滞剂进行实验性钳制。他们预计，阻断睡眠剥夺相关的血压升高将防止炎症标志物的上升。他们还将检验一个假设，即中等脂肪的人更容易遭受急性睡眠剥夺的炎症和自主神经后果。在本研究的筛选数据中，将研究肥胖、心血管健康、C反应蛋白和习惯性睡眠持续时间和质量之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent studies have shown that mediators of inflammation, useful in predicting risk of developing cardiovascular disease in healthy asymptomatic individuals, are also increased by experimental sleep deprivation. Low basal increases in inflammatory markers are also seen in "metabolic syndrome" and the researchers hypothesize that inadequate or insufficient sleep may be a pivotal contributing factor in the development of metabolic syndrome. The researchers hypothesize that basal changes in inflammation are actually secondary to cardiovascular factors associated with shear stress, using a placebo controlled study where the increase of blood pressure that is known to ensue during sleep deprivation is experimentally clamped, through the use of a beta blocker. They expect that blocking sleep deprivation associated increase in blood pressure will prevent the rise of inflammatory markers. They will also test the hypothesis that moderately adipose individuals are at greater risk to suffer the inflammatory and autonomic consequences of acute sleep deprivation. In screening date from this study, the relationship between adiposity, cardiovascular fitness, C-reactive protein, and habitual sleep duration and quality will be looked at.