Repeated challenge of insufficient sleep: Effects on endothelial function

睡眠不足的反复挑战：对内皮功能的影响

基本信息

批准号：
8633472
负责人：
JANET M MULLINGTON
金额：
$ 75.98万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-03-01 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8633472
关键词：
Adult Age American Awareness Behavior Therapy Behavioral Blood Circulation Blood Pressure Blood Vessels Cardiovascular Diseases Catecholamines Cell Adhesion Molecules Data Death Rate Dependence Development Disease Electroencephalography Endothelial Cells Epidemiology Exposure to Fasting Frequencies Health Homeostasis Host Defense Host Defense Mechanism Hour Human Hypertension Imaging Techniques Impairment Individual Inflammation Inflammation Mediators Inflammatory Interleukin-6 Leukocyte Adhesion Molecules Leukocyte-Adhesion Receptors Light Link Measurement Measures Mediating Metabolic Modeling National Health and Nutrition Examination Survey Norepinephrine Occupations Pattern Perfusion Peripheral Physiological Population Production Recovery Reporting Research Design Risk Risk Factors Risk Marker Sampling Sleep Sleep Architecture Sleep Deprivation Slow-Wave Sleep Societies System Testing Time Up-Regulation Vascular System Vasodilation Woman Work Writing attributable mortality brachial artery cardiovascular disorder risk cardiovascular risk factor cost design diet and exercise efficacy testing member men peripheral blood pressure research study response sleep regulation smoking cessation

项目摘要

DESCRIPTION (provided by applicant): The 24-hour-a-day, 7-day a week, work-world arrived within our lifetimes, and is here to stay. Americans are working more and more, frequently at multiple jobs. The pattern of short sleep during the week followed by attempts to recover on the weekend is in common practice, but we know little of the associated health risks. What is the cost in terms of increasing known risk markers for cardiovascular disease, of repeated nights of insufficient sleep, and is this cost compounded with repetition, without adequate recovery? Evidence is accumulating to suggest that short sleep duration is linked to the development of metabolic and inflammation-associated diseases, such as cardiovascular disease. Mechanisms involved in the development of cardiovascular disease include impaired vascular function and inflammation. The current application is designed to investigate the effects of repeated periods of short nocturnal sleep duration in 4 cycles (each cycle consisting of 3 nights of 4 hours of sleep opportunity per night), and each cycle of short sleep followed by a single night of recovery sleep. Vascular reactivity will be assessed using brachial artery flow mediated dilation, and microcirculatory vasodilation will be assessed using perfusion imaging techniques. The dependence of IL-6 and sVCAM-1 as measured in peripheral circulation, on vascular function, will also be investigated.

描述（由申请人提供）：每天24小时，每周7天，工作世界在我们的一生之内到达，并将留在这里。美国人的工作越来越多，经常从事多个工作。一周中睡眠短暂的模式，然后是在周末进行康复的尝试，但我们几乎不知道相关的健康风险。在增加心血管疾病的已知风险标记，反复睡眠不足的夜晚，这种成本的成本是多少，而这种成本是否会重复重复，而没有足够的恢复？有证据表明，短时间睡眠时间与代谢和炎症相关疾病（例如心血管疾病）的发展有关。涉及心血管疾病发展的机制包括血管功能和炎症受损。当前的应用旨在研究4个周期中短夜间睡眠持续时间重复时期的影响（每个周期包括每晚4个小时的睡眠机会的3晚），每个短睡眠的循环，然后是一个晚上的恢复睡眠。将使用臂动脉流介导的扩张来评估血管反应性，并将使用灌注成像技术评估微循环血管舒张。还将研究在周围循环中测量的IL-6和SVCAM-1对血管功能的依赖性。