ADIPOSITY, BP, AND THE INFLAMMATORY RESPONSE TO SLEEP LOSS

肥胖、血压和睡眠不足引起的炎症反应

• 批准号: 7718892
• 负责人: JANET M MULLINGTON
• 金额: $ 1.48万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718892
• 关键词: Acute; Adipose tissue; Adrenergic beta-Antagonists; Blood Pressure; Cardiovascular Diseases; Cardiovascular system; Computer Retrieval of Information on Scientific Projects Database; Development; Funding; Grant; Individual; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Institution; Metabolic syndrome; Obesity; Research; Research Personnel; Resources; Risk; Secondary to; Sleep; Sleep Deprivation; Source; Testing; United States National Institutes of Health; placebo controlled study; prevent; shear stress

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent studies have shown that mediators of inflammation, useful in predicting risk of developing cardiovascular disease in healthy asymptomatic individuals, are also increased by experimental sleep deprivation. Low basal increases in inflammatory markers are also seen in "metabolic syndrome" and the researchers hypothesize that inadequate or insufficient sleep may be a pivotal contributing factor in the development of metabolic syndrome. The researchers hypothesize that basal changes in inflammation are actually secondary to cardiovascular factors associated with shear stress, using a placebo controlled study where the increase of blood pressure that is known to ensue during sleep deprivation is experimentally clamped, through the use of a beta blocker. They expect that blocking sleep deprivation associated increase in blood pressure will prevent the rise of inflammatory markers. They will also test the hypothesis that moderately adipose individuals are at greater risk to suffer the inflammatory and autonomic consequences of acute sleep deprivation.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 最近的研究表明，通过实验睡眠剥夺，炎症介质有助于预测健康无症状个体患心血管疾病的风险。在“代谢综合征”中还可以看到炎症标记的基础低增加，研究人员假设睡眠不足或不足可能是代谢综合征发展的关键因素。研究人员假设炎症的基础变化实际上是与剪切应力相关的心血管因素继发的，使用安慰剂对照研究，在这种研究中，通过使用Beta阻滞剂，可以在实验中夹紧睡眠剥夺期间已知的血压升高。他们预计，阻塞睡眠剥夺与血压的升高有关，将阻止炎症标志物的上升。他们还将检验以下假设：中度脂肪个体遭受急性睡眠剥夺的炎症和自主性后果的风险更大。