Limits of Multi-Tetrode Intracortical Microstimulation

描述（由申请人提供）：尚未完全了解初级听觉皮层微刺激的空间和时间模式如何影响塞莫那肽的质量。本申请的主要目标是使用大鼠的行为测定来研究通过植入在麻醉大鼠的初级听觉皮层中的多个四极阵列的皮层内微刺激（ICMS）的空间模式诱发的感觉感知的限制。该应用程序将确定听觉皮层的单极和三极微刺激之间是否存在感知差异，并通过行为检查四极内（35 - 50微米）和四极之间（100 - 250微米）的ICMS质量。行为条件动物的使用有可能成为多位点模式化微刺激引起的安普肽质量的强有力指示。通过这个应用程序确定的电诱发的听觉感知的空间限制将有助于未来的皮质神经假体的设计。这项工作在开发和设计能够以人工唤起听觉感知的方式刺激听觉皮层的电子脑机接口方面具有潜在的重要意义。

DESCRIPTION (provided by applicant): It is not fully understood how spatial and temporal patterns of microstimulation of primary auditory cortex affect the quality of percept. The principle goal of this application is to use behavioral assays in rats to investigate the limits of sensory perceptions evoked by spatial patterns of intracortical microstimulation (ICMS) through multiple tetrode arrays implanted in primary auditory cortex of deafened rat. This application will determine if perceptual differences exist between monopolar and tripolar microstimulation of auditory cortex, and examine the quality of ICMS within (35 - 50 micrometers) and between (100 - 250 micrometers) tetrodes, through behavior. The use of behaviorally conditioned animals has the potential to be a strong indication of the quality of percept elicited by multi-site patterned microstimulation. The spatial limits of electrically-evoked auditory percepts determined through this application will aid in the design of future cortical neuroprosthetics. This work is of potentially great relevance in the development and design of an electrical brain-machine interface capable of stimulating auditory cortex in such a manner as to artificially evoke auditory perceptions.