CORE--Exposure and Biomarker

在目前的资助期间，暴露和生物标记核心为中心的研究项目提供了关键的暴露监测、生物标记分析和建模服务。这项研究导致了关于环境暴露在生长发育和哮喘中所起作用的各种重要的新发现。在接下来的工作中，核心建议通过评估儿童发展过程中的暴露情况，在这些发现的基础上再接再厉并加以扩展。除了支持哮喘和生长发育社区参与性研究(CBPR)项目的病因学目标外，CORE还将继续开发和建设一个重要的数据库，内容涉及曼哈顿北部和南布朗克斯地区暴露于多环芳烃(PAH)、非持久性杀虫剂(NPP)、环境烟草烟雾(ETS)、过敏原(蟑螂、老鼠、尘螨、猫和狗)、内毒素和霉菌的分布和决定因素。将成果转化为社区外展和教育、风险评估和干预发展是一个中心目标。 核心的具体目标是： 目的1.描述从怀孕到儿童早期暴露于PAH、NPP、ETS、过敏原、内毒素和霉菌的队列特征。 目的2.确定环境暴露、基因多态和营养水平的特征，以支持中心研究人员正在进行的关于易感因素(社会逆境、基因多态和营养缺陷)对风险的调节的研究，如CBRP哮喘和生长与发育项目中所概述的那样。 目的3.根据社区外联翻译和应用核心(COTAC)的活动，确定暴露和营养不足的特征，以支持关于社区外联和教育、风险评估和制定减少暴露战略研究结果的翻译工作。

Over the current funding period, the Exposure and Biomarker Core has provided key exposure monitoring, biomarker analysis, and modeling services for Center research projects. This research has resulted in a variety of important new findings regarding the roles played by environmental exposures in growth and development and asthma. In the continuation, the Core proposes to build on and extend these findings by assessing exposures over the time course of child development. In addition to supporting the etiologic aims of the community-based participatory research (CBPR) projects on Asthma and Growth and Development, the Core will continue to develop and build an important database on the distributions and determinants of exposures to polycyclic aromatic hydrocarbon (PAH), non-persistent pesticides (NPP), environmental tobacco smoke (ETS), allergens (cockroach, mouse, dust mite, cat and dog), endotoxins, and molds in northern Manhattan and the South Bronx. Translation of results for community outreach and education, risk assessment, and intervention development is a central aim. Specific aims of the Core are to: Aim 1. Characterize cohort exposures from pregnancy through the early childhood time periods to: PAH, NPP, ETS, allergens, endotoxins and molds. Aim 2. Characterize environmental exposures, genetic polymorphisms and nutritional levels to support the research being conducted by Center investigators on the modulation of risks by susceptibility factors (social adversity, genetic polymorphisms and nutritional deficits) as outlined in the CBRP projects on Asthma and Growth and Development. Aim 3. Characterize exposures and nutritional deficits to support the research on the translation of findings for community outreach and education, risk assessments, and development of strategies for exposure reduction as outlined in the activities of the Community Outreach Translation and Application Core (COTAC).