Calcium Foods and Bone Health of Adolescent Girls

钙食物与青春期女孩的骨骼健康

• 批准号: 6825745
• 负责人: JOAN LAPPE
• 金额: $ 17.81万
• 依托单位: CREIGHTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6825745
• 关键词: Calcium; Foods; Bone; Health; Adolescent

EXCEED THE SPACE PROVIDED, Osteoporosis is a major public health problem. Optimum development of the skeleton during youth is crucial in prevention of osteoporosis, a condition in which fractures occur late in life because of reduced bone mass and bone quality. If skeletal development can be maximized during growth, young people will begin adulthood with optimal bone health and be less likely to develop osteoporosis in later years. Yet bone health of youth has not been adequately addressed. In this application, we propose to extend our 4-year intervention study of the effects of a high calcium diet on bone quality in pubertal girls. The aim of this experimental study is to test the effect of increasing dietary calcium intake to 1500 mg/day on increases in bone quality in adolescent females. The hypothesis to be tested is: adolescent females who consume a high calcium diet will have a greater increase in bone quality, as measured by densitometry and ultrasound, than adolescent females who consume their usual dietary calcium intake. The study uses an experimental design in which 58 participants (26 treatment and 32 control) will be followed for a total of 9.5 years. Participants are a convenience sample who were age 9 when enrolled. Girls in the treatment group will continue to be given high calcium foods to supply at least 1500 mg/day, while girls in the control group will asked to continue consuming their usual diet. Measurements to be made at baseline, every six months, and at the end of study include: bone quality determined with densitometry and ultrasound, height, weight, Tanner stage, and medical and social history. Usual physical activity and dietary intake will be determined every three months. Funding of this project in the next cycle would enable us to follow these young females continuously from age 9 to 18.5. To our knowledge, this would be the first intervention to evaluate the effects of optimal calcium intake on bone health throughout the period of highest bone mass and bone quality accrual. It is critical that we take advantage of this opportunity. This enthusiastic group of adolescent participants provides us with confidence that we can successfully complete this ambitious project. Evidence of a positive effect of increased calcium intake from food sources on bone quality in adolescent females would provide strong support for educational efforts targeted at adolescent females, parents and care providers. Positive findings would also provide the impetus for calcium fortification of more foods that appeal to young females. Lack of a calcium effect would provide support for further research into other methods or concomitant methods of maximizing skeletal development. PERFORMANCE SITE ========================================Section End===========================================

骨质疏松症是一个重大的公共卫生问题。青少年时期骨骼的最佳发育对于预防骨质疏松症至关重要，骨质疏松症是一种由于骨量和骨质量下降而在晚年发生骨折的疾病。如果骨骼在生长过程中能够得到最大程度的发育，年轻人将以最佳的骨骼健康状态开始成年，并且在以后的几年中患骨质疏松症的可能性较小。然而，青少年的骨骼健康尚未得到充分解决。在本申请中，我们建议延长为期 4 年的干预研究，研究高钙饮食对青春期女孩骨质量的影响。本实验研究的目的是测试将膳食钙摄入量增加至 1500 毫克/天对青春期女性骨质量增加的影响。待检验的假设是：通过密度测量和超声波测量，食用高钙饮食的青春期女性的骨质量比食用平常膳食钙摄入量的青春期女性有更大的提高。该研究采用实验设计，对 58 名参与者（26 名治疗组和 32 名对照组）进行总共 9.5 年的跟踪调查。参与者是一个方便样本，注册时年龄为 9 岁。治疗组的女孩将继续摄入高钙食物，每天至少提供1500毫克的钙，而对照组的女孩将被要求继续日常饮食。在基线、每六个月和研究结束时进行的测量包括：通过密度测量和超声确定的骨质量、身高、体重、坦纳分期以及医疗和社会史。通常的体力活动和饮食摄入量将每三个月确定一次。下一个周期对该项目的资助将使我们能够持续跟踪这些年轻女性从 9 岁到 18.5 岁。据我们所知，这将是第一个评估最佳钙摄入量对骨量和骨质量最高增长期间骨骼健康影响的干预措施。我们必须利用这个机会。这群热情的青少年参与者让我们充满信心，相信我们能够成功完成这个雄心勃勃的项目。有证据表明，增加食物来源的钙摄入量对青春期女性的骨质量具有积极影响，这将为针对青春期女性、父母和护理人员的教育工作提供强有力的支持。积极的发现也将为更多吸引年轻女性的食物的钙强化提供动力。缺乏钙效应将为进一步研究其他方法或最大化骨骼发育的伴随方法提供支持。表演网站==========================================章节结束===============================================