Calcium Foods and Bone Health of Adolescent Girls

超过提供的空间，骨质疏松症是一个主要的公共卫生问题。年轻时骨骼的最佳发育对于预防骨质疏松症至关重要，骨质疏松症是一种由于骨量和骨质量下降而在晚年发生骨折的情况。如果骨骼在生长过程中得到最大限度的发展，年轻人将以最佳的骨骼健康开始成年，并在以后的几年里不太可能发生骨质疏松症。然而，年轻人的骨骼健康问题还没有得到充分解决。在这项应用中，我们建议延长我们为期4年的干预研究，研究高钙饮食对青春期女孩骨骼质量的影响。这项实验研究的目的是测试将膳食钙摄入量增加到1500毫克/天对提高青春期女性骨骼质量的影响。要检验的假设是：通过密度测量和超声波测量，食用高钙饮食的青春期女性骨骼质量的增加幅度将比通常摄入钙的青春期女性更大。这项研究采用了一项实验设计，其中58名参与者(26名治疗组和32名对照组)将被跟踪调查，总共为期9.5年。参与者是一个方便的样本，他们在登记时年满9岁。治疗组的女孩将继续摄入高钙食物，每天至少供应1500毫克，而对照组的女孩将被要求继续摄入他们通常的饮食。在基线、每六个月和研究结束时进行的测量包括：通过密度测量和超声波测定的骨质量、身高、体重、皮肤晒黑阶段以及病史和社会史。通常的体力活动和饮食摄入量将每三个月确定一次。在下一个周期为这个项目提供资金将使我们能够从9岁持续跟踪这些年轻女性到18.5岁。据我们所知，这将是第一次评估在骨量和骨质量最高的时期最佳钙摄入量对骨健康的影响。我们利用这个机会是至关重要的。这群热情的青少年参与者使我们充满信心，相信我们能够成功完成这一雄心勃勃的项目。来自食物来源的钙摄入量增加对青春期女性骨骼质量有积极影响的证据将为针对青春期女性、父母和护理提供者的教育努力提供强有力的支持。积极的发现也将为更多吸引年轻女性的食物补钙提供动力。缺乏钙效应将为进一步研究最大化骨骼发育的其他方法或伴随方法提供支持。表演网站========================================Section End===========================================

EXCEED THE SPACE PROVIDED, Osteoporosis is a major public health problem. Optimum development of the skeleton during youth is crucial in prevention of osteoporosis, a condition in which fractures occur late in life because of reduced bone mass and bone quality. If skeletal development can be maximized during growth, young people will begin adulthood with optimal bone health and be less likely to develop osteoporosis in later years. Yet bone health of youth has not been adequately addressed. In this application, we propose to extend our 4-year intervention study of the effects of a high calcium diet on bone quality in pubertal girls. The aim of this experimental study is to test the effect of increasing dietary calcium intake to 1500 mg/day on increases in bone quality in adolescent females. The hypothesis to be tested is: adolescent females who consume a high calcium diet will have a greater increase in bone quality, as measured by densitometry and ultrasound, than adolescent females who consume their usual dietary calcium intake. The study uses an experimental design in which 58 participants (26 treatment and 32 control) will be followed for a total of 9.5 years. Participants are a convenience sample who were age 9 when enrolled. Girls in the treatment group will continue to be given high calcium foods to supply at least 1500 mg/day, while girls in the control group will asked to continue consuming their usual diet. Measurements to be made at baseline, every six months, and at the end of study include: bone quality determined with densitometry and ultrasound, height, weight, Tanner stage, and medical and social history. Usual physical activity and dietary intake will be determined every three months. Funding of this project in the next cycle would enable us to follow these young females continuously from age 9 to 18.5. To our knowledge, this would be the first intervention to evaluate the effects of optimal calcium intake on bone health throughout the period of highest bone mass and bone quality accrual. It is critical that we take advantage of this opportunity. This enthusiastic group of adolescent participants provides us with confidence that we can successfully complete this ambitious project. Evidence of a positive effect of increased calcium intake from food sources on bone quality in adolescent females would provide strong support for educational efforts targeted at adolescent females, parents and care providers. Positive findings would also provide the impetus for calcium fortification of more foods that appeal to young females. Lack of a calcium effect would provide support for further research into other methods or concomitant methods of maximizing skeletal development. PERFORMANCE SITE ========================================Section End===========================================