A Vervet Monkey(Cercopithecus Aethiops) Genetic Map

黑长尾猴（Cercopithecus Aethiops）遗传图谱

• 批准号: 6935339
• 负责人: NELSON B. FREIMER
• 金额: $ 83.01万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6935339
• 关键词: Cercopithecidae; Internet; behavioral genetics; developmental genetics; ethology; fluorescent in situ hybridization; gene expression; gene expression profiling; genetic library; genetic mapping; genetic markers; genetic polymorphism; genome; genotype; linkage mapping; magnetic resonance imaging; microarray technology; molecular biology information system; phenotype; polymerase chain reaction; population genetics; single nucleotide polymorphism; technology /technique development

DESCRIPTION (provided by applicant): This is the renewal of a project that is developing an integrated genetic resource for investigations of complex traits in the vervet monkey (Cercopithecus aethiops), also known as the African Green monkey. Genetic investigation of complex traits will increasingly include a combination of traditional genetic mapping with identification of candidate genes through gene expression profiling. The renewal of this project will produce an integrated genomewide genetic reference map consisting of microsatellite and single nucleotide polymorphism (SNP) markers. The development of a microarray resource, covering a wide range of brain and non-brain tissues, at several points of development will enable investigations of gene expression in the vervet. Magnetic resonance imaging (MRI) studies will provide anatomic guidance for dissection of brain tissues for microarrays. The tools generated from this project will facilitate investigation of a wide range of human diseases and traits, including complex behaviors and infectious diseases. The utility of such studies derives from the fact that humans are much more similar to other primates than they are to other model organisms such as the mouse. The worldwide shortage of rhesus macaques for biomedical research has created a tremendous need for alternative non-human primate models. Vervets share many biological and behavioral similarities with macaques and are readily available to researchers. This project will further enhance the value of the vervet for biomedical research.

描述（由申请人提供）：这是一个项目的更新，该项目正在开发一种综合遗传资源，用于研究非洲长尾猴（Cercopithecus aethiops）的复杂特征，也被称为非洲绿色猴。复杂性状的遗传研究将越来越多地包括传统遗传作图与通过基因表达谱鉴定候选基因的结合。该项目的更新将产生由微卫星和单核苷酸多态性（SNP）标记组成的全基因组遗传参考图谱。微阵列资源的发展，涵盖了广泛的脑和非脑组织，在几个发展点将使调查的基因表达的长尾。磁共振成像（MRI）研究将为微阵列的脑组织解剖提供解剖学指导。该项目产生的工具将有助于调查各种人类疾病和特征，包括复杂行为和传染病。这些研究的实用性源于这样一个事实，即人类与其他灵长类动物的相似性远远超过与其他模式生物（如小鼠）的相似性。全球范围内用于生物医学研究的恒河猴短缺，导致了对替代非人类灵长类动物模型的巨大需求。长尾猴与猕猴在生物学和行为上有许多相似之处，研究人员很容易找到它们。这一项目将进一步提高黑尾鹿在生物医学研究中的价值。