African Americans with Glaucoma: Structure and Function

患有青光眼的非洲裔美国人：结构和功能

• 批准号: 6951138
• 负责人: PAMELA A SAMPLE
• 金额: $ 173.45万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6951138
• 关键词: African American; blindness; caucasian American; cell morphology; clinical research; cooperative study; eye disorder diagnosis; eye fundus photography; glaucoma; human subject; longitudinal human study; medical complication; nerve injury; optic nerve; pathologic process; perimetry; racial /ethnic difference; tomography; vision disorders; vision tests; visual fields

DESCRIPTION (provided by applicant): Glaucoma, which is 5 times more likely to occur in Blacks than Whites, is the leading cause of irreversible blindness in Blacks. Little is known about whether new diagnostic tests including vision function specific tests and optic disc and retinal nerve fiber layer imaging can improve our ability to detect and monitor glaucoma in the Black population. Purpose: To systematically assess and compare new diagnostic techniques in Black and White participants. Aims: To compare differences in visual function tests and measures of optic nerve structure in normal, ocular hypertensive, and glaucomatous Black and White participants, to determine whether function specific perimetry tests show improved diagnosis in Blacks as they do in Whites, and to compare the rate and patterns of progression of glaucomatous damage in the two racial groups. Participants: 125 normal and 275 Black participants with glaucoma. Methods: Black participants will be recruited primarily from New York Eye and Ear Infinnary and the University of Alabama Glaucoma Service. White participants are recruited under separate funding at UC San Diego. UC San Diego serves as a Reading Center for data processing, quality control and analysis for this study. The glaucomatous eyes will be followed with annual testing for 5 years. Visual fields will include standard clinical perimetry, and two function-specific tests, Short-wavelength Automated Perimetry and Frequency Doubling Technology Perimetry. Optic nerve structure will be qualitatively evaluated with stereoscopic fundus photography and quantitatively using the Heidelberg Retina Tomograph and Optical Coherence Tomograph. Comparisons between Blacks and Whites will be made on each test and between the measures of function and structure. Importance: At study conclusion, practitioners should understand any differences in visual function and optic nerve structure between White and Black patients and how to account for them when interpreting the results. A greater understanding of the importance of race for development and progression of glaucoma will result leading to more precise endpoints for future clinical trials with this at-risk minority population.

描述（由申请人提供）：青光眼在黑人中发生的可能性是白人的 5 倍，是黑人不可逆性失明的主要原因。人们对新的诊断测试（包括视觉功能特异性测试以及视盘和视网膜神经纤维层成像）是否可以提高我们检测和监测黑人青光眼的能力知之甚少。目的：系统评估和比较黑人和白人参与者的新诊断技术。目的：比较正常、高眼压和青光眼黑人和白人参与者的视功能测试和视神经结构测量的差异，以确定功能特异性视野检查是否显示黑人与白人的诊断得到改善，并比较两个种族组中青光眼损伤进展的速度和模式。 参与者：125 名正常人和 275 名患有青光眼的黑人参与者。方法：黑人参与者将主要从纽约眼耳医院和阿拉巴马大学青光眼服务中心招募。 白人参与者是在加州大学圣地亚哥分校的单独资助下招募的。加州大学圣地亚哥分校作为本研究的数据处理、质量控制和分析的阅读中心。青光眼眼睛将在 5 年内每年进行一次检查。视野将包括标准临床视野检查和两项特定功能测试：短波长自动视野检查和倍频技术视野检查。 将通过立体眼底摄影对视神经结构进行定性评估，并使用海德堡视网膜断层扫描仪和光学相干断层扫描仪进行定量评估。将在每次测试以及功能和结构测量之间进行黑人和白人之间的比较。 重要性：在研究结论中，从业者应了解白人和黑人患者之间视觉功能和视神经结构的差异，以及在解释结果时如何解释这些差异。更好地了解种族对青光眼发生和进展的重要性将为未来针对这一高危少数群体的临床试验带来更精确的终点。