African Descent and Glaucoma Evaluation Study (ADAGES)

非洲人后裔和青光眼评估研究 (ADAGES)

• 批准号: 7613614
• 负责人: PAMELA A SAMPLE
• 金额: $ 40万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7613614
• 关键词: Accounting; African; African American; Age; Alabama; Blindness; Clinical; Clinical Trials; Databases; Defect; Depth; Development; Diagnosis; Diagnostic Procedure; Diagnostic tests; Ear; Early Diagnosis; Evaluation Studies; Eye; Frequencies; Funding; Fundus photography; Future; Glaucoma; Image; Measures; Methods; Minority; Monitor; Nerve; New York; Ocular Hypertension; Optic Disk; Optic Nerve; Optics; Participant; Patients; Pattern; Perimetry; Population; Quality Control; Race; Rate; Recruitment Activity; Research Personnel; Retina; Risk; Sclera; Services; Standards of Weights and Measures; Structure; Technology; Testing; Time; Universities; Vision; Visual Fields; computerized data processing; improved; novel diagnostics; optic cup; retinal nerve fiber layer; stereoscopic

Glaucoma, which is 5 times more likely to occur in Blacks than Whites, is the leading cause of irreversible blindness in Blacks. Little is known about whether new diagnostic tests including vision function specific tests and optic disc and retinal nerve fiber layer imaging can improve our ability to detect and monitor glaucoma in the Black population.Purpose: To systematicallyassess and compare new diagnostic techniques in Black and White participants. Aims: To compare differences in visual function tests and me^ures of optic nerve structure in normal, ocular hypertensive, and glaucomatous Black and White participants,to determine whetherfunction specific perimetry tests show improved diagnosis in Blacks as they do in Whites, and to^compare the rate and patterns of progression of glaucomatous damage in the two racial groups! Participants: 125 normal and 275 Black participants with glaucoma. Methods: Black participants will be recruited primarilyfrom New York Eye and Ear Infirmary and the University of Alabama Glaucoma Service. White participants are recruited under separate funding at UC San Diego. UC San Diego serves as aReading Center for data processing, quality control and analysis for this study. The glaucomatous eyes will be followed with annual testing for 5 years. Visual fields will include standard clinical perimetry, and two function-specific tests, Short-wavelength Automated Perimetry and Frequency Doubling Technology Perimetry. Optic nerve structure will be qualitatively evaluated with stereoscopic fundus photography and quantitatively using the Heidelberg Retina Tomograph and Optical Coherence Tomograph.Comparisons between Blacks and Whites will be made on each test and between the measures of function and structure. Importance: At study conclusion,practitioners should understand any differences in visual function and optic nerve structure between White and Black patients and how to account for them when interpretingthe results. A greater understandingof the importanceof race for development and progression of glaucoma will result leading to more precise endpointsfor future clinical trials with this at-risk minority population.

青光眼，这是5倍更容易发生在黑人比白人，是不可逆转的主要原因， 黑人的失明关于包括视觉功能特异性在内的新的诊断测试是否 检查和视盘和视网膜神经纤维层成像可以提高我们检测和监测 目的：系统评价和比较新的诊断技术 黑人和白色参与者。目的：比较视觉功能测试和测量的差异， 正常人、高眼压者和昏迷黑人和白色人的视神经结构， 确定功能特异性视野检查在黑人中是否显示出与在白人中一样的诊断改善， 并比较两个种族群体中昏迷损害进展的速度和模式！ 参与者：125名正常人和275名患有青光眼的黑人参与者。方法：黑人参与者将 主要从纽约眼耳医院和亚拉巴马大学青光眼服务中心招募。 白色参与者是在加州大学圣地亚哥分校单独资助下招募的。加州大学圣地亚哥分校作为一个阅读 本研究的数据处理、质量控制和分析中心。昏迷的眼睛会 每年进行一次测试，为期5年。视野将包括标准临床视野检查，以及两个 特定功能测试、短波长自动视野检查和倍频技术 视野检查。视神经结构将通过立体眼底摄影进行定性评价， 使用海德堡视网膜断层扫描仪和光学相干断层扫描仪进行定量比较。 黑人和白人之间的差异将在每次测试中以及功能和结构的措施之间进行。 重要性：在研究结束时，从业者应了解视觉功能的任何差异， 白色和黑色患者之间的视神经结构以及在解释 结果更好地理解青光眼发展和进展的重要性， 这一结果为未来的临床试验提供了更精确的终点，这些临床试验针对的是处于风险中的少数人群。