COLOR VISION IN PRIMARY OPEN ANGLE GLAUCOMA

原发性开角型青光眼的色觉

• 批准号: 2162091
• 负责人: PAMELA A SAMPLE
• 金额: $ 19.83万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2162091
• 关键词: aging; anterior chamber; color visions; diagnosis design /evaluation; diagnosis quality /standard; disease /disorder proneness /risk; glaucoma; human subject; longitudinal human study; optic disk; pathology; perimetry; psychophysics; visual fields; visual photosensitivity

This proposal outlines psychophysical research techniques designed to study the changes in human color vision associated with primary open angle glaucoma. An improved understanding of the underlying functional changes in color vision caused by glaucoma will be addressed by measurement of fine discriminations along both chromatic and achromatic dimensions. Color perimetry using the procedures described in this proposal has been found to successfully differentiate glaucoma suspect and primary open angle glaucoma patients from normal age-matched controls. Long-term follow-up of these patients will determine the ability of the test to predict which ocular hypertensive eyes are most at risk for development glaucoma before topographic changes in the optic disc and standard visual field become apparent, and whether the test can used to monitor effectiveness of medical therapies employed in glaucoma. Finally, methods are incorporated which will determine the proportion of sensitivity loss due to normal aging on both standard white-on-white and color visual fields. Differentiation of age-related changes due to increased absorption of light by the ocular media and those due to retinal or neural changes will be possible. This will provide new information to assist in accurate diagnosis and treatment.

该提案概述了旨在研究的心理物理学研究技术 与主要开角相关的人类色觉变化 青光眼。 更好地理解潜在的功能变化 由青光眼引起的色觉将通过测量精细度来解决 沿彩色和消色差维度的辨别。 使用本提案中描述的程序进行颜色视野测量已 发现可以成功区分疑似青光眼和原发性开角型青光眼 青光眼患者来自正常年龄匹配的对照。 长期跟踪 这些患者将决定测试的能力来预测哪些 高眼压眼在发病前最有可能发生青光眼 视盘和标准视野的地形变化变得 显而易见，以及该测试是否可以用于监测医疗效果 用于青光眼的疗法。 最后，结合一些方法来确定 由于标准白底白纸和白底白纸的正常老化而导致灵敏度损失 彩色视野。 区分与年龄相关的变化 眼介质和视网膜对光的吸收增加 或神经变化将是可能的。 这将为 协助准确诊断和治疗。