African Descent and Glaucoma Evaluation Study (ADAGES)

描述（由申请人提供）：青光眼是黑人不可逆失明的主要原因，黑人发生青光眼的可能性是白人的5倍。对于新的诊断测试，包括视觉功能特异性测试和视盘和视网膜神经纤维层成像，是否能提高我们检测和监测黑人青光眼的能力，我们知之甚少。目的：系统地评估和比较黑人和白人参与者的新诊断技术。目的：比较正常、高眼压和青光眼黑人和白人受试者视觉功能检查和视神经结构测量的差异，确定功能特异性验光检查在黑人中的诊断是否比在白人中更好，并比较两个种族群体青光眼损害的进展速度和模式。参与者：125名正常人和275名患有青光眼的黑人参与者。方法：黑人参与者将主要从纽约眼耳医院和阿拉巴马大学青光眼服务中心招募。白人参与者是在加州大学圣地亚哥分校的单独资助下招募的。加州大学圣地亚哥分校作为本研究的数据处理、质量控制和分析的阅读中心。青光眼患者随访5年，每年检查一次。视野将包括标准的临床视野检查，以及两个功能特定的测试，短波自动视野检查和倍频技术视野检查。视神经结构将通过立体眼底摄影进行定性评估，并通过海德堡视网膜断层摄影和光学相干断层摄影进行定量评估。黑人和白人将在每个测试中进行比较，并在功能和结构的测量之间进行比较。重要性：在研究结论中，医生应该了解白人和黑人患者在视觉功能和视神经结构上的任何差异，以及在解释结果时如何解释这些差异。更好地了解种族对青光眼发展和进展的重要性，将为未来针对这一高危少数人群的临床试验提供更精确的终点。

DESCRIPTION (provided by applicant): Glaucoma, which is 5 times more likely to occur in Blacks than Whites, is the leading cause of irreversible blindness in Blacks. Little is known about whether new diagnostic tests including vision function specific tests and optic disc and retinal nerve fiber layer imaging can improve our ability to detect and monitor glaucoma in the Black population. Purpose: To systematically assess and compare new diagnostic techniques in Black and White participants. Aims: To compare differences in visual function tests and measures of optic nerve structure in normal, ocular hypertensive, and glaucomatous Black and White participants, to determine whether function specific perimetry tests show improved diagnosis in Blacks as they do in Whites, and to compare the rate and patterns of progression of glaucomatous damage in the two racial groups. Participants: 125 normal and 275 Black participants with glaucoma. Methods: Black participants will be recruited primarily from New York Eye and Ear Infinnary and the University of Alabama Glaucoma Service. White participants are recruited under separate funding at UC San Diego. UC San Diego serves as a Reading Center for data processing, quality control and analysis for this study. The glaucomatous eyes will be followed with annual testing for 5 years. Visual fields will include standard clinical perimetry, and two function-specific tests, Short-wavelength Automated Perimetry and Frequency Doubling Technology Perimetry. Optic nerve structure will be qualitatively evaluated with stereoscopic fundus photography and quantitatively using the Heidelberg Retina Tomograph and Optical Coherence Tomograph. Comparisons between Blacks and Whites will be made on each test and between the measures of function and structure. Importance: At study conclusion, practitioners should understand any differences in visual function and optic nerve structure between White and Black patients and how to account for them when interpreting the results. A greater understanding of the importance of race for development and progression of glaucoma will result leading to more precise endpoints for future clinical trials with this at-risk minority population.