African Descent And Glaucoma Evaluation Study (ADAGES)

非洲人后裔与青光眼评估研究 (ADAGES)

• 批准号: 7313869
• 负责人: PAMELA A SAMPLE
• 金额: $ 209.9万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7313869
• 关键词: Accounting; African; Algorithms; Area; Blindness; Characteristics; Clinical; Defect; Detection; Development; Diagnosis; Disease; Documentation; Early Diagnosis; Enrollment; European; Evaluation Studies; Event; Eye; Fiber; Fundus photography; Genetic Risk; Glaucoma; Goals; Grant; Histopathology; Hypertension; Image; Imaging Device; Impairment; Individual; Longitudinal Studies; Measurement; Measures; Medical; Methods; Modeling; Monitor; Optic Disk; Optic Nerve; Participant; Patient Self-Report; Patients; Pattern; Perimetry; Persons; Population; Procedures; Race; Retina; Retinal; Risk; Risk Assessment; Risk Factors; Role; Structure; Testing; Time; Vision; Visual Fields; cohort; design; follow-up; high risk; improved; optic nerve disorder; predictive modeling; retinal nerve fiber layer; stereoscopic

DESCRIPTION (provided by applicant): Glaucoma is 5 times more likely to occur in persons of African descent (AD) than in those of European descent (ED) and is the leading cause of blindness in AD individuals. The African Descent And Glaucoma Evaluation Study (ADAGES) is the first prospectively designed multi-center, longitudinal study to follow a well-characterized cohort of glaucoma patients of African Descent on a variety of measures of visual function, optic nerve structure, risk assessment, and clinical results. Purpose: To identify what factors account for the differences in glaucoma onset and rate of progression found between individuals of African descent and those of European descent and to determine whether accounting for these differences can be used to optimize algorithms for detection of glaucoma and for monitoring progression. Aims: To quantify differences in visual function and structure of the retina in glaucomatous individuals from the two ancestry groups. To combine information from structural and functional measures improving both diagnosis and follow-up of progressive glaucoma using modeling of predictive and risk factors, including self-reported race versus genetically determined ancestry. Participants: 364 healthy individuals (218 AD) and 860 patients (693 AD) with or at risk for glaucoma have completed baseline testing and are being followed. Methods: Patient eyes will be followed with annual testing for 5 additional years on standard clinical perimetry, and two function-specific tests. Optic nerve structure will be qualitatively evaluated with stereoscopic fundus photography and quantitatively using three retinal imaging devices. Importance: At the conclusion of this study, practitioners should be able to understand any differences in visual function and optic nerve structure between the two ancestry groups, and how to account for them when interpreting the results from both the routine and promising new procedures evaluated in this study. Better documentation of the magnitude and rate of glaucomatous changes will assist clinicians in determining whether and how aggressively patients should be treated. A greater understanding of the importance of ancestry and other risk factors for development and progression of glaucoma will result.

描述（由申请人提供）：非洲人后裔 (AD) 患青光眼的可能性是欧洲人后裔 (ED) 的 5 倍，并且是导致 AD 人失明的主要原因。非洲人后裔和青光眼评估研究 (ADAGES) 是第一个前瞻性设计的多中心纵向研究，旨在跟踪一组特征明确的非洲人后裔青光眼患者，对视觉功能、视神经结构、风险评估和临床结果进行各种测量。目的：确定哪些因素导致非洲裔和欧洲裔个体之间青光眼发病和进展速度的差异，并确定这些差异是否可用于优化青光眼检测和监测进展的算法。目的：量化两个血统青光眼个体视觉功能和视网膜结构的差异。结合结构和功能测量的信息，使用预测和风险因素（包括自我报告的种族与基因决定的血统）建模，改善进行性青光眼的诊断和随访。参与者：364 名健康个体 (218 AD) 和 860 名患有青光眼或有青光眼风险的患者 (693 AD) 已完成基线测试并正在进行随访。方法：在接下来的 5 年中，将每年对患者眼睛进行标准临床视野检查和两项功能特异性测试的跟踪。将通过立体眼底摄影对视神经结构进行定性评估，并使用三种视网膜成像设备进行定量评估。重要性：在本研究结束时，从业者应该能够理解两个祖先群体之间视觉功能和视神经结构的任何差异，以及在解释本研究中评估的常规和有希望的新程序的结果时如何解释这些差异。更好地记录青光眼变化的程度和发生率将有助于临床医生确定是否应该以及如何积极地治疗患者。人们将更好地了解血统和其他风险因素对青光眼发生和进展的重要性。