African Descent And Glaucoma Evaluation Study (ADAGES)

描述（由申请人提供）：非洲裔（AD）患者发生青光眼的可能性是欧洲裔（艾德）患者的5倍，是AD患者失明的主要原因。非洲裔和青光眼评价研究（ADAGES）是第一项前瞻性设计的多中心纵向研究，旨在通过各种视觉功能，视神经结构，风险评估和临床结果来跟踪非洲裔青光眼患者的良好特征队列。目的：确定哪些因素导致了非洲裔和欧洲裔个体之间青光眼发作和进展速度的差异，并确定这些差异是否可用于优化青光眼检测和监测进展的算法。目的：量化来自两个祖先群体的青光眼个体的视觉功能和视网膜结构的差异。结合联合收割机的结构和功能测量信息，通过预测和风险因素的建模，包括自我报告的种族与遗传决定的祖先，改善进行性青光眼的诊断和随访。参加人员：364名健康个体（218名AD）和860名患有青光眼或有青光眼风险的患者（693名AD）已完成基线测试并正在接受随访。方法：将对患者眼睛进行额外5年的标准临床视野检查和两项功能特异性检查。视神经结构将通过立体眼底摄影进行定性评价，并使用三种视网膜成像设备进行定量评价。重要性：在本研究结束时，从业者应该能够理解两个祖先群体之间视觉功能和视神经结构的任何差异，以及在解释本研究中评估的常规和有前途的新程序的结果时如何解释它们。更好地记录颅内血肿变化的程度和速度将有助于临床医生确定是否以及如何积极治疗患者。更好地理解祖先的重要性和青光眼发展和进展的其他危险因素将导致。

DESCRIPTION (provided by applicant): Glaucoma is 5 times more likely to occur in persons of African descent (AD) than in those of European descent (ED) and is the leading cause of blindness in AD individuals. The African Descent And Glaucoma Evaluation Study (ADAGES) is the first prospectively designed multi-center, longitudinal study to follow a well-characterized cohort of glaucoma patients of African Descent on a variety of measures of visual function, optic nerve structure, risk assessment, and clinical results. Purpose: To identify what factors account for the differences in glaucoma onset and rate of progression found between individuals of African descent and those of European descent and to determine whether accounting for these differences can be used to optimize algorithms for detection of glaucoma and for monitoring progression. Aims: To quantify differences in visual function and structure of the retina in glaucomatous individuals from the two ancestry groups. To combine information from structural and functional measures improving both diagnosis and follow-up of progressive glaucoma using modeling of predictive and risk factors, including self-reported race versus genetically determined ancestry. Participants: 364 healthy individuals (218 AD) and 860 patients (693 AD) with or at risk for glaucoma have completed baseline testing and are being followed. Methods: Patient eyes will be followed with annual testing for 5 additional years on standard clinical perimetry, and two function-specific tests. Optic nerve structure will be qualitatively evaluated with stereoscopic fundus photography and quantitatively using three retinal imaging devices. Importance: At the conclusion of this study, practitioners should be able to understand any differences in visual function and optic nerve structure between the two ancestry groups, and how to account for them when interpreting the results from both the routine and promising new procedures evaluated in this study. Better documentation of the magnitude and rate of glaucomatous changes will assist clinicians in determining whether and how aggressively patients should be treated. A greater understanding of the importance of ancestry and other risk factors for development and progression of glaucoma will result.