African Americans with Glaucoma: Structure and Function

患有青光眼的非洲裔美国人：结构和功能

• 批准号: 6804697
• 负责人: PAMELA A SAMPLE
• 金额: $ 171.29万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6804697
• 关键词: African American; blindness; caucasian American; cell morphology; clinical research; cooperative study; eye disorder diagnosis; eye fundus photography; glaucoma; human subject; longitudinal human study; medical complication; nerve injury; optic nerve; pathologic process; perimetry; racial /ethnic difference; tomography; vision disorders; vision tests; visual fields

DESCRIPTION (provided by applicant): Glaucoma, which is 5 times more likely to occur in Blacks than Whites, is the leading cause of irreversible blindness in Blacks. Little is known about whether new diagnostic tests including vision function specific tests and optic disc and retinal nerve fiber layer imaging can improve our ability to detect and monitor glaucoma in the Black population. Purpose: To systematically assess and compare new diagnostic techniques in Black and White participants. Aims: To compare differences in visual function tests and measures of optic nerve structure in normal, ocular hypertensive, and glaucomatous Black and White participants, to determine whether function specific perimetry tests show improved diagnosis in Blacks as they do in Whites, and to compare the rate and patterns of progression of glaucomatous damage in the two racial groups. Participants: 125 normal and 275 Black participants with glaucoma. Methods: Black participants will be recruited primarily from New York Eye and Ear Infinnary and the University of Alabama Glaucoma Service. White participants are recruited under separate funding at UC San Diego. UC San Diego serves as a Reading Center for data processing, quality control and analysis for this study. The glaucomatous eyes will be followed with annual testing for 5 years. Visual fields will include standard clinical perimetry, and two function-specific tests, Short-wavelength Automated Perimetry and Frequency Doubling Technology Perimetry. Optic nerve structure will be qualitatively evaluated with stereoscopic fundus photography and quantitatively using the Heidelberg Retina Tomograph and Optical Coherence Tomograph. Comparisons between Blacks and Whites will be made on each test and between the measures of function and structure. Importance: At study conclusion, practitioners should understand any differences in visual function and optic nerve structure between White and Black patients and how to account for them when interpreting the results. A greater understanding of the importance of race for development and progression of glaucoma will result leading to more precise endpoints for future clinical trials with this at-risk minority population.

描述（由申请人提供）：青光眼，这是5倍更容易发生在黑人比白人，是不可逆转的失明的主要原因在黑人。新的诊断测试，包括视觉功能特异性测试和视盘和视网膜神经纤维层成像是否可以提高我们在黑人人群中检测和监测青光眼的能力，目前还知之甚少。目的：在黑人和白色参与者中系统地评估和比较新的诊断技术。目的：比较正常、高眼压和青光眼患者中黑人和白色受试者的视功能检查和视神经结构测量的差异，以确定功能特异性视野检查是否显示黑人的诊断与白人一样得到改善，并比较两个种族组中青光眼损害进展的速率和模式。 参与者：125名正常人和275名患有青光眼的黑人参与者。方法：黑人参与者将主要从纽约眼耳医院和亚拉巴马大学青光眼服务中心招募。 白色参与者是在加州大学圣地亚哥分校单独资助下招募的。加州大学圣地亚哥分校作为本研究的数据处理、质量控制和分析的阅读中心。将对患眼进行随访，每年进行一次检测，持续5年。视野将包括标准临床视野检查和两项特定功能检查，即短波长自动视野检查和倍频技术视野检查。 视神经结构将通过立体眼底摄影进行定性评价，并使用海德堡视网膜断层扫描仪和光学相干断层扫描仪进行定量评价。黑人和白人之间的比较将在每一个测试和功能和结构的措施。 重要性：在研究结束时，从业者应了解白色和黑人患者之间在视觉功能和视神经结构方面的任何差异，以及在解释结果时如何解释这些差异。更好地理解种族对青光眼发展和进展的重要性，将导致未来在这一高危少数人群中进行的临床试验的终点更精确。