Development of arousal and attention regulation

觉醒和注意力调节的发展

• 批准号: 6983669
• 负责人: BERNARD Z KARMEL
• 金额: $ 9.71万
• 依托单位: INSTITUTE FOR BASIC RES IN DEV DISABIL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6983669
• 关键词: arousal; attention; behavioral /social science research tag; brain injury; child psychology; clinical research; developmental disease /disorder; developmental neurobiology; executive function; gait; human subject; infant human (0-1 year); longitudinal human study; neuropsychological tests; neuroregulation; open field behavior; paralinguistic behavior; personality; prenatal stress; preschool child (1-5); psychomotor function; questionnaires; speech disorders

The primary goal of this project is to understand how the early ability to modulate motor behavior forms the basis for the development of motor regulation over the early years of life, and how this process is modified by acute CNS injury and chronic stress on the developing nervous system. It extends our ongoing work by examining arousal effects on motor regulation while addressing practical issues associated with assessment and understanding of early precursors to developmental disabilities. Specific aims are (1) to study spontaneous and elicited motor activity during the neonatal period, including how this is modulated by arousal and related to attention modulation during this period, (2) to study specific hypothesis-driven marker tasks involving various sensory and environmental inputs on motor regulation from the neonatal period through the pre-school years (from newborn to 5 years), (3) to relate the ability to modulate motor activity in the early months of life to later autoregulatory components of motor behavior, (4) to evaluate the effect of chronic stress and acute CNS injury on this developmental process of motor regulation, and (5) to integrate findings on motor regulation with the types of dysfunction in motor skill that are prevalent in our high-risk population. While most studies of CNS injury and motor development in high-risk infants and children concentrate on factors such as incidence and degree of gross motor disabilities, this Subproject will look beyond direct and obvious damage to motor pathways by examining the effects of CNS injury from acute and chronic insult on the infant's ability to modulate motor activity. Studies will examine infants' modulation of early spontaneous and elicited movements, older infants' modulation of motor behavior under various sensory, cognitive, environmental, and social demands. The design is a longitudinal prospective study with 2 cohorts: 330 newly-recruited infants from the NICU tested from birth to 34 months and 275 previously-recruited children tested from 34 - 60 months. The longitudinal character of the study and its integration of motor regulation results from neonates through pre-schoolers with information on early injury, early attention-modulation capacity, and executive-function and linguistic development promise not only to advance theoretical knowledge of motor development and regulation but to suggest potential strategies for therapeutic intervention. This Subproject will use information on autoregulation from Core procedures as well as on gestures and social communication from Subproject II as they contribute to motor regulation.

该项目的主要目标是了解运动行为的早期调节能力如何形成生命早期运动调节发展的基础，以及这一过程如何被急性中枢神经系统损伤和发育中的神经系统的慢性应激所改变。它扩展了我们正在进行的工作，通过检查唤醒对运动调节的影响，同时解决与评估和理解发育障碍早期前兆相关的实际问题。具体目的是：(1)研究自发运动和诱发运动