COCAINE EFFECTS ON ATTENTION AND AROUSAL IN NEONATES

可卡因对新生儿注意力和觉醒的影响

基本信息

项目摘要

We hypothesize that because of cocaine's effect on the developing catecholamine system, prenatal cocaine exposure (CE) should interfere with the infant's ability to regulate and control arousal. This effect produces a style of responding to the environment that is characterized by seeking stimulation more than usual and is hypothesized to affect normal development of attention and subsequent behavior. Thus, CE infants will differ in how they integrate arousal and attention as compared to (a) non- CE infants, and (b) infants with other CNS risk conditions. Furthermore, we hypothesize that these differences should persist through the first 19 months of age and be detected primarily using tasks that require control of stimulation. Strong evidence now indicates that CE infants tend to look at more stimulating events regardless of manipulations of arousal that would normally shift attention to less stimulating events. Current aims are designed to manipulate a vanity of situations for which hypothesized responses with respect to stimulation can be evaluated. First, we predict that CE infants during the newborn period, in contrast to both normal infants and infants with documented CNS pathology, will display this stimulus-seeking behavior in a number of different converging tasks in which arousal is manipulated by feeding or amount of stimulation. Second, we propose to extend the study of the interaction of early CE with developmental changes in attention and perception to determine whether development of short-term memory and of response to stimulus change, complex patterns, and auditory-visual synchrony are altered. We predict that CE, acting through the substrate of early arousal/attention organization, will interfere with the normal development of these processes when evaluated at specific intervals during the first year. Third, we propose to determine if there is a relationship of early cocaine exposure with (a) perceptual and motivational development between 10 and 19 months, as measured by focused attention, distractibility, and exploratory behavior and (b) general cognitive growth particularly as altered by CNS status. Finally we wish to determine if the different developmental trajectory of mental function observed in CE infants reflects CNS injury, differential environmental experience, or intrauterine CE by studying infants of cocaine using mothers seeking rehabilitation program. A 5-year project initially studying 384 infants, with 192 completing all aspects of the study is proposed.
我们假设由于可卡因对发育中的 儿茶酚胺系统,产前可卡因暴露(CE)应干扰 婴儿调节和控制性唤起的能力这种效应产生 一种以寻求为特征的对环境做出反应的风格 刺激比平常更多,并假设影响正常 注意力和后续行为的发展。因此,CE婴儿将 不同的是,他们如何整合唤醒和注意力相比,(a)非- CE婴儿,和(B)具有其它CNS风险状况的婴儿。此外,委员会认为, 我们假设这些差异应该持续到前19个月, 月龄,主要通过需要控制的任务来检测 的刺激。强有力的证据表明,CE婴儿往往看起来 在更刺激的事件中, 通常会把注意力转移到不那么刺激的事情上。目前的目标 被设计来操纵一种虚幻的情况, 可以评估关于刺激的响应。首先,我们预测 CE婴儿在新生儿期,与正常 婴儿和有CNS病理记录的婴儿,将显示这一点, 刺激寻求行为在一些不同的收敛任务, 这种唤醒是通过进食或刺激量来控制的。第二、 我们建议扩展早期CE与 注意力和知觉的发展变化,以确定是否 发展短期记忆和对刺激变化的反应, 复杂的模式和视觉同步性被改变。我们预测 CE通过早期唤醒/注意的基底起作用, 组织,会干扰这些的正常发展 在第一年的特定时间间隔进行评估时, 第三,我们建议确定早期可卡因是否与 (a)10岁至20岁之间的知觉和动机发展 19个月,通过集中注意力、注意力分散和 探索行为和(B)一般认知增长,特别是 因中枢神经系统状态而改变。最后,我们希望确定不同的 CE婴儿心理功能发育轨迹观察 反映CNS损伤、不同的环境经历,或 通过研究使用母亲寻求可卡因的婴儿的子宫内CE 康复计划。一个为期5年的项目,最初研究384名婴儿, 建议192人完成研究的所有方面。

项目成果

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BERNARD Z KARMEL其他文献

BERNARD Z KARMEL的其他文献

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{{ truncateString('BERNARD Z KARMEL', 18)}}的其他基金

Development of arousal and attention regulation
觉醒和注意力调节的发展
  • 批准号:
    6983669
  • 财政年份:
    2005
  • 资助金额:
    $ 64.1万
  • 项目类别:
COCAINE EFFECTS ON AROUSAL AND ATTENTION IN NEONATES
可卡因对新生儿的唤醒和注意力的影响
  • 批准号:
    2118836
  • 财政年份:
    1990
  • 资助金额:
    $ 64.1万
  • 项目类别:
COCAINE EFFECTS ON ATTENTION AND AROUSAL IN NEONATES
可卡因对新生儿注意力和觉醒的影响
  • 批准号:
    2458378
  • 财政年份:
    1990
  • 资助金额:
    $ 64.1万
  • 项目类别:
COCAINE EFFECTS ON ATTENTION AND AROUSAL IN NEONATES
可卡因对新生儿注意力和觉醒的影响
  • 批准号:
    6174631
  • 财政年份:
    1990
  • 资助金额:
    $ 64.1万
  • 项目类别:
COCAINE EFFECTS ON ATTENTION AND AROUSAL IN NEONATES
可卡因对新生儿注意力和觉醒的影响
  • 批准号:
    2749063
  • 财政年份:
    1990
  • 资助金额:
    $ 64.1万
  • 项目类别:
COCAINE EFFECTS ON AROUSAL AND ATTENTION IN NEONATES
可卡因对新生儿的唤醒和注意力的影响
  • 批准号:
    3213312
  • 财政年份:
    1990
  • 资助金额:
    $ 64.1万
  • 项目类别:
COCAINE EFFECTS ON AROUSAL AND ATTENTION IN NEONATES
可卡因对新生儿的唤醒和注意力的影响
  • 批准号:
    2118835
  • 财政年份:
    1990
  • 资助金额:
    $ 64.1万
  • 项目类别:
COCAINE EFFECTS ON ATTENTION AND AROUSAL IN NEONATES
可卡因对新生儿注意力和觉醒的影响
  • 批准号:
    2659886
  • 财政年份:
    1990
  • 资助金额:
    $ 64.1万
  • 项目类别:
COCAINE EFFECTS ON ATTENTION AND AROUSAL IN NEONATES
可卡因对新生儿注意力和觉醒的影响
  • 批准号:
    2649309
  • 财政年份:
    1990
  • 资助金额:
    $ 64.1万
  • 项目类别:
COCAINE EFFECTS ON AROUSAL AND ATTENTION IN NEONATES
可卡因对新生儿的唤醒和注意力的影响
  • 批准号:
    3213313
  • 财政年份:
    1990
  • 资助金额:
    $ 64.1万
  • 项目类别:

相似国自然基金

基于Valence-Arousal空间的维度型中文文本情感分析研究
  • 批准号:
    61702443
  • 批准年份:
    2017
  • 资助金额:
    29.0 万元
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How Does Attention and Arousal Interact to Modulate Vision?
注意力和唤醒如何相互作用来调节视力?
  • 批准号:
    10386446
  • 财政年份:
    2022
  • 资助金额:
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  • 项目类别:
How Does Attention and Arousal Interact to Modulate Vision?
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  • 批准号:
    10578681
  • 财政年份:
    2022
  • 资助金额:
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Role of the midline thalamus in arousal, attention and cognition
中线丘脑在唤醒、注意力和认知中的作用
  • 批准号:
    8573930
  • 财政年份:
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Influence of Attention and Arousal on Sensory Abnormalities in ASD
注意力和唤醒对自闭症谱系障碍感觉异常的影响
  • 批准号:
    8352042
  • 财政年份:
    2012
  • 资助金额:
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Influence of Attention and Arousal on Sensory Abnormalities in ASD
注意力和唤醒对自闭症谱系障碍感觉异常的影响
  • 批准号:
    8509789
  • 财政年份:
    2012
  • 资助金额:
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Electrophysiological measures of arousal and attention following total sleep deprivation
完全睡眠剥夺后觉醒和注意力的电生理测量
  • 批准号:
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  • 财政年份:
    2010
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Arousal and Attention Regulation in High Risk Children
高危儿童的唤醒和注意力调节
  • 批准号:
    7892739
  • 财政年份:
    2009
  • 资助金额:
    $ 64.1万
  • 项目类别:
Arousal and Attention Regulation in High Risk Children
高危儿童的唤醒和注意力调节
  • 批准号:
    7439148
  • 财政年份:
    2005
  • 资助金额:
    $ 64.1万
  • 项目类别:
MODULATION OF AROUSAL AND ATTENTION
调节唤醒和注意力
  • 批准号:
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  • 资助金额:
    $ 64.1万
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EMOTIONAL MODULATION OF ATTENTION AND AROUSAL
注意力和唤醒的情绪调节
  • 批准号:
    7375649
  • 财政年份:
    2005
  • 资助金额:
    $ 64.1万
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