GORDON RESEARCH CONFERENCE ON RADIATION ONCOLOGY

申请人简介申请资助戈登研究会议，主题为“放射肿瘤学中的细胞和分子概念”，会议将于2001年1月28日至2月2日在加利福尼亚州文图拉举行。申请的资金将全部用于支持代表年轻教职员工的特邀演讲者的旅费和注册费，以及为在会议上张贴海报的年轻调查人员提供部分支持。在我们对控制细胞对电离辐射反应的因素的理解方面，继续取得了非常迅速的进展。本次会议的目标是审查和讨论有关辐射损害细胞的细胞和分子机制的最新数据。这将通过以下方式实现：从一系列在其研究领域具有领导地位的专家中挑选受邀的发言者进行演讲，提供海报介绍，并举行全体讨论会，所有与会者都参加会议。会议的一个具体目标是在非正式环境中将青年研究人员与更资深的科学家聚集在一起，以促进广泛的互动和鼓励思想的自由交流。预计将有大约100至130名与会者参加会议，他们是从大学、研究机构以及政府和工业研究实验室中挑选出来的。科学会议将确定正在出现令人兴奋的新信息的领域。这些会议包括：1)辐射反应中的重组过程；2)损伤识别途径；3)氧化应激；4)损伤反应途径；5)辐射诱导的基因组不稳定；6)哺乳动物细胞死亡的机制；7)新的辐射模型；8)翻译模型；9)旁观者效应。还将举行四次会议，让所有与会者分享他们在与会议有关的领域进行的最新研究的详细情况。其中一些海报，特别是年轻调查人员展示的海报，将被选为简短的平台演示文稿。会议的一个压倒一切的目标是，初级和高级科学家之间在所代表的各个领域的交流将产生新的想法，并产生富有成效的合作。

APPLICANT'S DESCRIPTION This is an application for support for the Gordon Research Conference on "Cellular and Molecular Concepts in Radiation Oncology" to be held in Ventura, CA on January 28-February 2, 2001. The funds requested will be used entirely for the support of travel and registration fees for invited speakers who represent younger faculty members, as well as partial support for young investigators presenting posters at the meeting. There continues to be extraordinary rapid progress in our understanding of the factors governing the response of cells to ionizing radiation. The goal of this Conference is to examine and discuss recent data concerning the cellular and molecular mechanisms by which radiation damages cells. This will be achieved through presentations by invited speakers selected from a range of experts who are leaders in their research areas, by proffered poster presentations, and by plenary discussion sessions involving all attendees at the meeting. A particular objective of the Conference is to bring together young investigators with more senior scientists in an informal setting that will facilitate wide-ranging interactions and encourage a free exchange of ideas. Approximately 100 to 130 participants are expected to attend the meeting, chosen from universities, research institutes and governmental and industrial research laboratories. The scientific sessions will define areas in which exciting new information is emerging. These sessions include: 1) recombinational processes in radiation response; 2) damage recognition pathways; 3) oxidative stress; 4) damage response pathways; 5) radiation- induced genomic instability; 6) mechanisms of mammalian cell death; 7) new radiation models; 8) translational models; and 9) bystander effects. Four poster sessions will also be featured for all conference participants to share details of their latest research in areas appropriate to the Conference. Some of these posters, especially those presented by young investigators, will be selected for short platform presentations. An overriding goal of the Conference is that the cross-fertilization between junior and senior scientists in the various areas represented will generate new ideas and spawn productive collaborations.