GORDON RESEARCH CONFERENCE ON RADIATION ONCOLOGY

这是一份申请，支持将于2001年1月28日至2月2日在加州文图拉举行的戈登研究会议“放射肿瘤学中的细胞和分子概念”。所要求的资金将全部用于支持代表年轻教员的受邀演讲者的旅费和注册费，以及部分支持在会议上展示海报的年轻研究人员。在我们对控制细胞对电离辐射的反应的因素的理解方面，继续有非常迅速的进展。本次会议的目的是审查和讨论有关辐射损伤细胞的细胞和分子机制的最新数据。这将通过从其研究领域的领导专家中挑选的特邀演讲者的演讲、提供海报展示以及所有与会者参加的全体讨论会议来实现。会议的一个特别目标是使年轻的研究人员与较资深的科学家在一个非正式的环境中聚集在一起，这将促进广泛的互动并鼓励自由交流思想。预计将有大约100至130名与会者参加会议，他们从大学、研究机构、政府和工业研究实验室中挑选出来。科学会议将确定令人兴奋的新信息正在出现的领域。这些会议包括：1)辐射反应的重组过程；2)损伤识别途径；3)氧化应激；4)损伤反应途径；5)辐射引起的基因组不稳定性；6)哺乳动物细胞死亡机制；7)新型辐射模型；8)翻译模型；9)旁观者效应。还将举办四场海报讨论会，供所有与会者分享他们在适合会议的领域的最新研究细节。其中一些海报，特别是那些由年轻研究人员提交的海报，将被选为简短的平台演讲。会议的一个压倒一切的目标是，所代表的各个领域的初级和高级科学家之间的相互交流将产生新的想法和产生富有成效的合作。

APPLICANT'S DESCRIPTION This is an application for support for the Gordon Research Conference on "Cellular and Molecular Concepts in Radiation Oncology" to be held in Ventura, CA on January 28-February 2, 2001. The funds requested will be used entirely for the support of travel and registration fees for invited speakers who represent younger faculty members, as well as partial support for young investigators presenting posters at the meeting. There continues to be extraordinary rapid progress in our understanding of the factors governing the response of cells to ionizing radiation. The goal of this Conference is to examine and discuss recent data concerning the cellular and molecular mechanisms by which radiation damages cells. This will be achieved through presentations by invited speakers selected from a range of experts who are leaders in their research areas, by proffered poster presentations, and by plenary discussion sessions involving all attendees at the meeting. A particular objective of the Conference is to bring together young investigators with more senior scientists in an informal setting that will facilitate wide-ranging interactions and encourage a free exchange of ideas. Approximately 100 to 130 participants are expected to attend the meeting, chosen from universities, research institutes and governmental and industrial research laboratories. The scientific sessions will define areas in which exciting new information is emerging. These sessions include: 1) recombinational processes in radiation response; 2) damage recognition pathways; 3) oxidative stress; 4) damage response pathways; 5) radiation- induced genomic instability; 6) mechanisms of mammalian cell death; 7) new radiation models; 8) translational models; and 9) bystander effects. Four poster sessions will also be featured for all conference participants to share details of their latest research in areas appropriate to the Conference. Some of these posters, especially those presented by young investigators, will be selected for short platform presentations. An overriding goal of the Conference is that the cross-fertilization between junior and senior scientists in the various areas represented will generate new ideas and spawn productive collaborations.