Magnetic Resonance Imaging of Coronary Arteries at 3.OT

描述（由申请人提供）： 冠状动脉疾病是美国人死亡的主要原因。该项目的总体目标是开发、优化和验证一种高分辨率磁共振（MR）成像方案，以无创地评估冠状动脉疾病。长期目标是为冠状动脉疾病提供一种非侵入性的筛查测试。该测试可能与MRI提供的其他血液动力学、功能和代谢研究相结合，形成冠状动脉疾病的全面检查，以改善患者护理并节省成本。该项目的具体目标是提高冠状动脉图像的空间分辨率、速度和信号强度。我们将在3.0特斯拉扫描仪上采集图像，该扫描仪可以生成比传统1.5特斯拉系统更高信号强度的图像。我们将在3.0T上开发和验证冠状动脉成像技术，并与1.5T进行比较，以验证性能的改善。最后，将对患者进行研究，通过与传统的X射线血管造影术进行比较，确定新技术在检测功能显著的冠状动脉狭窄方面的能力。本研究的积极结果将为进一步的技术改进和临床验证提供基础。本项目的具体目的是：目的1：开发一种能够采集高分辨率图像的快速3.0T冠状动脉造影方案，以准确定义血管管腔大小目的2：验证所开发的3.0T冠状动脉MRA方案能够准确描述猪冠状动脉狭窄; 3.0T图像信噪比和狭窄检测准确性优于1.5T目标3：证明所开发的3.0T成像方案能够准确检测患者的冠状动脉疾病。

DESCRIPTION (provided by applicant): Coronary artery disease is the leading cause of death in the United States. The overall objective of the proposed project is to develop, optimize, and validate a high resolution magnetic resonance (MR) imaging protocol to evaluate coronary artery disease noninvasively. The long-term goal is to provide a noninvasive screening test for coronary artery disease. This test could potentially be combined with other hemodynamic, functional, and metabolic studies available from MRI to form a comprehensive examination of coronary artery disease for improved patient care and cost savings. The specific goal of the project is to improve the spatial resolution, speed, and signal intensity of coronary artery images. We will acquire the images on a 3.0-Tesla scanner which can generate images with high signal intensity than conventional 1.5-Tesla systems. We will develop and validate the coronary artery imaging techniques on 3.0T and compare with 1.5T to verify the improved performance. Finally, patients will be studied to determine the capability of the new technique in detecting functionally significant coronary artery stenoses by comparing with conventional x-ray angiography. Positive results from this study will provide the foundation for further technical improvements and clinical validation. The specific aims of the project are: Aim 1: To develop a fast coronary artery angiography protocol on 3.0T capable of acquiring high-resolution images to accurately define vessel lumen size Aim 2: To verify that the developed coronary MRA protocol on 3.0T can accurately depict coronary artery stenoses in pigs; image SNR and accuracy of stenosis detection on 3.0T are better than those on 1.5T Aim 3: To demonstrate that the developed imaging protocol on 3.0T can accurately detect coronary artery disease in patients.