The neurobiology of disease: a comprehensive graduate curriculum

描述(由申请者提供)：这是一份关于开发一个综合的疾病神经生物学课程的建议，包括一个概述课程和一组12-16个新的、半学期的疾病神经生物学课程“模块”，为期三年。模块将为研究生提供广泛的神经和精神疾病/障碍/状况的病理生物学和临床方面的深入培训。一些模块将围绕许多神经系统疾病的共同生物主题进行组织；其他模块将围绕特定的疾病/状况进行组织。所有模块的课程将包括：疾病/状况的临床演示，包括患者演示；病理生物学；疾病机制与其他疾病的共同之处；基础科学如何转化为特定领域的临床试验；临床试验设计和实施的基础；以及针对特定患者群体的以患者为导向的研究中的伦理问题。课程形式将包括基础和临床教师的讲座、学生报告、阅读当前文献的作业、小组讨论。目前存在的疾病神经生物学概述课程(宾夕法尼亚大学已经开设了20多年)，并将继续提供。所有模块都将由来自多个系的临床和基础科学教师共同开发和教授。任何大学项目的研究生都可以入学；大多数学生来自生物医学研究生研究的八个领域之一，或者来自心理学、生物学、生物医学工程系，或者来自兽医学院和护理学院。将鼓励博士后研究员、住院医生和医学生注册、审计和/或个人使用所开发的材料。宾夕法尼亚大学任何时候都有600多名相关基础科学专业的研究生可能会对这些课程感兴趣。为概述课程和单元开发的所有材料，包括课程讲稿和详细课堂讲稿的幻灯片，都将为网络教育量身定做，并可在网络上免费获得。授予资格的T32培训补助金是5T32GM007517-26 Nusbaum，Michael，“系统与综合生物学研究生培训”。宾夕法尼亚大学还有另外两笔神经科学培训补助金，可以授予资格。与公共健康相关：该项目将开发和实施一个新的全面课程，向神经科学研究生(即博士生)传授各种神经系统疾病、损伤和精神疾病。学生们将学习患者的生活如何受到影响，以及故障导致临床问题的生物机制。学生们将讨论过去是如何开发治疗方法的，以及他们在实验室的研究如何有助于在未来开发新的治疗方法。

DESCRIPTION (provided by applicant): This is a proposal to develop a comprehensive Neurobiology of Disease curriculum, consisting of an overview course and a group of 12-16 new, half-semester Neurobiology of Disease course "Modules" offered over a three year cycle. Modules will provide graduate students with in-depth training in the pathobiology and clinical aspects of a wide range of neurological and psychiatric diseases/ disorders/ conditions. Some Modules will be organized around biological themes common across many nervous system disorders; others will be organized around specific diseases/ conditions. The curriculum for all Modules will include: clinical presentation of the disease/condition, including a patient presentation; pathobiology; disease mechanisms in common with other disorders; how basic science has translated into clinical trials in the given area; basics of clinical trial design and conduct; and ethical issues in patient-oriented research for the particular patient population. Course formats will include lectures by basic and clinical faculty, student presentations, reading assignments from the current literature, small group discussions. The Neurobiology of Disease overview course that exists currently (and has, at Penn, for more than 20 years) and will continue to be offered. All Modules will be developed and co-taught by both clinical and basic science faculty from multiple departments. Graduate students in any University program may enroll; most will come from one the eight areas of Biomedical Graduate Studies, or from the Departments of Psychology, Biology, Biomedical Engineering, or from the Schools of Veterinary Medicine and Nursing. Post doctoral research fellows, medical residents and medical students will be encouraged to enroll, audit and/or make individual use of the materials developed. There are more than 600 graduate students in relevant basic science program at Penn at any given time who likely would be interested in these courses. All materials developed for the overview course and Modules, including slides from course lectures and detailed lecture notes, will be tailored for web education and be made freely available on the web. The T32 training grant that confers eligibility is 5T32GM007517-26 Nusbaum, Michael, "Graduate Training in Systems and Integrative Biology." Penn also has two other neuroscience training grants that would have conferred eligibility. Relevance to public health: This project will develop and implement a new and comprehensive curriculum to teach neuroscience graduate students (i.e., PhD students) about various neurological diseases and injuries and psychiatric conditions. Students will learn how patients' lives are affected, and about the biological mechanisms that malfunction to cause the clinical problem. Students will discuss how treatments have been developed in the past, and how their research in a laboratory can help to lead to new treatment in the future.