The neurobiology of disease: a comprehensive graduate curriculum

疾病的神经生物学：综合研究生课程

• 批准号: 7125066
• 负责人: MARC A DICHTER
• 金额: $ 5.4万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7125066
• 关键词: Internet; clinical trials; curriculum; education evaluation /planning; educational resource design /development; neurobiology; neuropathology; patient oriented research; science education; training

DESCRIPTION (provided by applicant): This is a proposal to develop a comprehensive Neurobiology of Disease curriculum, consisting of an overview course and a group of 12-16 new, half-semester Neurobiology of Disease course "Modules" offered over a three year cycle. Modules will provide graduate students with in-depth training in the pathobiology and clinical aspects of a wide range of neurological and psychiatric diseases/ disorders/ conditions. Some Modules will be organized around biological themes common across many nervous system disorders; others will be organized around specific diseases/ conditions. The curriculum for all Modules will include: clinical presentation of the disease/condition, including a patient presentation; pathobiology; disease mechanisms in common with other disorders; how basic science has translated into clinical trials in the given area; basics of clinical trial design and conduct; and ethical issues in patient-oriented research for the particular patient population. Course formats will include lectures by basic and clinical faculty, student presentations, reading assignments from the current literature, small group discussions. The Neurobiology of Disease overview course that exists currently (and has, at Penn, for more than 20 years) and will continue to be offered. All Modules will be developed and co-taught by both clinical and basic science faculty from multiple departments. Graduate students in any University program may enroll; most will come from one the eight areas of Biomedical Graduate Studies, or from the Departments of Psychology, Biology, Biomedical Engineering, or from the Schools of Veterinary Medicine and Nursing. Post doctoral research fellows, medical residents and medical students will be encouraged to enroll, audit and/or make individual use of the materials developed. There are more than 600 graduate students in relevant basic science program at Penn at any given time who likely would be interested in these courses. All materials developed for the overview course and Modules, including slides from course lectures and detailed lecture notes, will be tailored for web education and be made freely available on the web. The T32 training grant that confers eligibility is 5T32GM007517-26 Nusbaum, Michael, "Graduate Training in Systems and Integrative Biology." Penn also has two other neuroscience training grants that would have conferred eligibility. Relevance to public health: This project will develop and implement a new and comprehensive curriculum to teach neuroscience graduate students (i.e., PhD students) about various neurological diseases and injuries and psychiatric conditions. Students will learn how patients' lives are affected, and about the biological mechanisms that malfunction to cause the clinical problem. Students will discuss how treatments have been developed in the past, and how their research in a laboratory can help to lead to new treatment in the future.

描述（由申请人提供）：这是一个建议，开发一个全面的疾病神经生物学课程，包括一个概述课程和一组12-16个新的，半学期的疾病神经生物学课程“模块”提供了一个为期三年的周期。模块将为研究生提供在广泛的神经和精神疾病/障碍/条件的病理生物学和临床方面的深入培训。一些模块将围绕许多神经系统疾病中常见的生物学主题进行组织;其他模块将围绕特定疾病/病症进行组织。所有模块的课程将包括：疾病/病症的临床表现，包括患者表现;病理生物学;与其他疾病共同的疾病机制;基础科学如何转化为给定领域的临床试验;临床试验设计和进行的基础知识;以及特定患者人群以患者为导向的研究中的伦理问题。课程形式将包括基础和临床教师的讲座，学生报告，当前文献的阅读作业，小组讨论。疾病的神经生物学概述课程，目前存在（并已在宾夕法尼亚大学，超过20年），并将继续提供。所有模块将由来自多个部门的临床和基础科学教师开发和共同教授。任何大学课程的研究生都可以入学;大多数将来自生物医学研究生课程的八个领域之一，或来自心理学，生物学，生物医学工程系，或来自兽医和护理学院。鼓励博士后研究员、住院医师和医科学生注册、审核和/或单独使用所开发的材料。在任何时候，宾夕法尼亚大学都有600多名研究生在从事相关的基础科学课程，他们可能会对这些课程感兴趣。为概述课程和模块编写的所有材料，包括课程讲座的幻灯片和详细的课堂讲稿，都将针对网络教育量身定制，并在网上免费提供。授予资格的T32培训补助金是5 T32 GM 007517 -26 Nusbaum，Michael，“系统和综合生物学研究生培训”。“宾夕法尼亚大学还有另外两个神经科学培训赠款，将授予资格。与公共卫生的相关性：该项目将开发和实施一个新的综合课程，教授神经科学研究生（即，关于各种神经系统疾病和损伤以及精神状况。学生将学习如何影响病人的生活，以及有关的生物机制，故障，导致临床问题。学生将讨论过去如何开发治疗方法，以及他们在实验室的研究如何有助于在未来开发新的治疗方法。