Postdoc Training in Translational Research in Neural Injury and Neurodegeneration

描述(由申请人提供)： 我们建议为完成神经学、神经外科、精神病学、眼科学、麻醉学、急诊医学或任何其他临床神经科学专业的临床培训，并渴望在疾病的神经生物学实验室进行翻译研究的医学博士或医学博士，提供神经损伤和神经退行性研究方面的综合培训计划。临床医生-科学家具有独特的能力来提出新的科学问题，受到患者观察的启发，并处于与博士科学家和医疗保健提供者沟通和合作的独特位置。该项目建立在指导关系的基础上，在这种关系中，两名经验丰富的教员培训师指导学员的研究发展。将选择导师为受训者提供补充经验。受训者将有机会进入宾夕法尼亚大学教职员工“核心”群体中的至少22个实验室，但也可以在其他实验室接受培训。实习生研究必须是协作的，提出至少与两个群体相关的问题。这项为期两年的计划将侧重于针对急性和慢性神经退行性疾病和条件的神经保护，包括中风；脑和脊髓损伤；阿尔茨海默氏症、帕金森氏症和运动神经元疾病；癫痫；视网膜变性；抑郁症；行为障碍；自闭症。培训将主要集中在实验室研究上，实习生项目旨在了解遗传、分子和细胞病理生理学以及预防、治疗或治愈策略的发展。授课培训将包括：大学疾病综合神经生物学课程的课程作业和临床试验方法学、拨款准备、统计学、生物伦理学、以患者为导向的研究和新药开发方面的研讨会。该计划将从2名实习生开始，在2年内增长到5名。拟议计划的一个独特特点是，未来的受训者将在他们的临床培训结束之前很久就知道他们被该计划接受了。这将使学员能够通过利用实习期间的时间获得研究和与研究相关的经验，为其专业发展的这一阶段制定计划，最终效果是扩大他们在撰写K奖提案之前获得的培训总量。预计完成该项目的学员将非常有竞争力地获得独立研究拨款，将成为学术医学中心的教员，并将从事疾病神经生物学方面的翻译研究。相关性：我们建议教授医生对神经系统疾病的病因进行实验室研究。更好的理解将导致新的治疗方法和治疗方法的发展。

DESCRIPTION (provided by applicant): We propose an integrative training program in translational research in neural injury and neurodegeneration for MDs or MD-PhDs who finish clinical training in Neurology, Neurosurgery, Psychiatry, Ophthalmology, Anesthesia, Emergency Medicine or any other clinical neuroscience specialty, and desire academic careers in laboratory-based translational research in the Neurobiology of Disease. Clinician-scientists have a unique ability to ask new scientific questions inspired by patient observations, and are singularly situated to communicate and collaborate with both PhD scientists and health care providers. The program is built around mentoring relationships in which two experienced faculty trainers guide a trainee's research development. Mentors will be chosen to offer complementary experience to the trainee. Trainees will have access to a minimum of 22 laboratories within the "core" group of Penn faculty, but could train in other laboratories as well. Trainee research must be collaborative, asking questions relevant to at least two groups. The 2-year program will focus on neuroprotection for acute and chronic neurodegenerative diseases and conditions, including stroke; brain and spinal cord injury; Alzheimer's, Parkinson's and motor neuron diseases; epilepsy; retinal degeneration; depression; behavioral disorders; autism. Training will focus heavily on laboratory research, with trainee projects directed toward understanding the genetic, molecular and cellular pathophysiology and the development of strategies for prevention, treatment, or cure. Didactic training will include: coursework in the University's comprehensive Neurobiology of Disease curriculum and workshops in clinical trial methodology, grant preparation, statistics, bioethics, patient-oriented research, and new drug development. The program would begin with 2 trainees, growing to 5 within 2 years. A unique feature of the proposed Program is that prospective trainees will know of their acceptance into the Program well before their clinical training ends. This will allow trainees to plan for this stage of their professional development by taking advantage of the time during residency to gain research, and research-related experience, with the final effect of expanding the total amount of training they will have acquired before writing their K-award proposal. It is expected that trainees who complete this program will be very competitive for independent research grant funding, will become faculty members at academic medical centers, and will pursue careers in translational research in the neurobiology of disease. Relevance: We propose to teach physicians to conduct laboratory research into causes of neurological diseases. A better understanding will lead to the development of new treatments and cures.