Remapping neurology through translation and innovation

通过翻译和创新重新映射神经病学

• 批准号: 9084668
• 负责人: MARC A DICHTER
• 金额: $ 21.54万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9084668
• 关键词: Neurology; Translations; innovation

 DESCRIPTION (provided by applicant): Clinician-scientists are uniquely positioned to ask new and insightful scientific questions inspired by patient observations, yet, they often lack the expertise to be able to translate their observations into carefully designed basic scientific and translational experiments. There are likely many reasons for this, but the most cited barriers are lack of specific training, mentoring, funding, and time. If these barriers could be removed, more highly motivated clinician-scientists could pursue careers in laboratory-based translational research, thereby helping to reverse the current state of affairs in many neurological disorders, in which basic research is proceeding at an increasingly rapid pace but translational research is lagging, and most patients with neurological disorders are left without effective treatments or cures. Here we propose a research training program for MD-PhDs or MDs who have finished their clinical training in a neuroscience-related specialty and are highly motivated to pursue careers as physician-scientists in innovative laboratory-based translational research in neurological diseases. The program consists of intense research training under the close mentoring of two faculty mentors, chosen to offer complementary experience. Trainees design and conduct independent multidisciplinary research projects that they can take with them when they transition to independent support, and upon which they will base their NIH K-award application. Research projects are directed toward the translation of the genetic, molecular and cellular pathophysiology of neurological diseases into strategies for prevention, treatment or cure. Trainees will be encouraged to pursue projects that are collaborative and cross-disciplinary, as collaboration fosters their research development, and linking disciplines helps generate ideas that are novel and innovative. Trainees will have access to 22 laboratories within the core faculty, but could collaborate with other groups as well. Trainees will work with PhD researchers; participate in journal clubs, lab meeting and basic science seminars. The curriculum includes a course on Neurobiology of Disease, a certificate program in patient-oriented research, which also covers experimental design and biostatistics, and structured discussions on critical topics in translational research. Trainees will also be exposed to the processes required to bring a therapy from the lab to the bedside, including instruction in clinica trial methodology and relevant regulatory issues. Trainees participate in workshops on developing a K- award proposal, grant and scientific writing, and laboratory and project management, plus mandatory training in responsible conduct of research. A unique feature of this Program is that prospective trainees can know of their acceptance before their clinical training ends, allowing them to schedule research into their remaining clinical time, thereby expanding the total amount of research experience they will have before writing a K- award proposal. The main expected short-term outcome for this program is application for an NIH K award.

 描述（由申请人提供）：临床医生-科学家具有独特的地位，可以提出受患者观察启发的新的和有见地的科学问题，然而，他们往往缺乏专业知识，无法将他们的观察转化为精心设计的基础科学和转化实验。这可能有很多原因，但最常见的障碍是缺乏具体的培训、指导、资金和时间。如果这些障碍可以被消除，更多积极性高的临床科学家可以从事以实验室为基础的转化研究，从而有助于扭转许多神经系统疾病的现状，其中基础研究正在以越来越快的速度进行，但转化研究却滞后，大多数神经系统疾病患者没有有效的治疗或治愈方法。在这里，我们提出了一个研究培训计划的MD-PhD或MD谁已经完成了他们的临床培训，在神经科学相关的专业，并高度积极地追求事业作为医生，科学家在创新的实验室为基础的转化研究神经疾病。该计划包括在两名教师导师的密切指导下进行密集的研究培训，选择提供补充经验。学员设计和进行独立的多学科研究项目，他们可以带着他们当他们过渡到独立的支持，并在此基础上，他们将他们的NIH K奖申请。研究项目旨在将神经系统疾病的遗传，分子和细胞病理生理学转化为预防，治疗或治愈的策略。将鼓励受训者从事合作和跨学科的项目，因为合作促进了他们的研究发展，而学科之间的联系有助于产生新颖和创新的想法。学员将有机会进入核心教师的22个实验室，但也可以与其他团体合作。学员将与博士研究人员一起工作;参加期刊俱乐部，实验室会议和基础科学研讨会。该课程包括疾病神经生物学课程，以患者为导向的研究证书课程，其中还包括实验设计和生物统计学，以及转化研究中关键主题的结构化讨论。学员还将接触到将治疗从实验室带到床边所需的过程，包括临床试验方法和相关监管问题的指导。受训人员参加关于制定K奖提案、赠款和科学写作、实验室和项目管理的讲习班，以及关于负责任地开展研究的强制性培训。该计划的一个独特之处在于，未来的学员可以在临床培训结束前知道他们被接受，从而使他们能够将研究安排在剩余的临床时间内，从而扩大他们在撰写K奖提案之前所拥有的研究经验总量。该计划的主要预期短期成果是申请NIH K奖。