High resolution cone beam volume CT for breast imaging

用于乳腺成像的高分辨率锥形束体积 CT

• 批准号: 6930519
• 负责人: RUOLA NING
• 金额: $ 58.77万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-03 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6930519
• 关键词: X ray; bioimaging /biomedical imaging; breast neoplasm /cancer diagnosis; clinical research; computed axial tomography; early diagnosis; female; human subject; image enhancement; mammography; phantom model; radiation dosage; technology /technique development; three dimensional imaging /topography; women' s health

DESCRIPTION (provided by applicant): The long term goal of this project is to develop a novel cone beam volume computed tomography breast imaging (CBVCTBI) technique to provide clinically useful three-dimensional (3D) high resolution tomographic images for breast cancer detection. CBVCTBI will require only a single fast volume scanning (4.8-9.6 seconds) to provide true 3D description of breast anatomy with 2.0-5.0 1p/mm isotropic resolution and will provide adequate low contrast resolution and high contrast spatial resolution for breast cancer detection.The clinical significance of CBVCTBI is that it will improve the sensitivity of breast cancer detection due to its much better low contrast resolution, compared to conventional mammography. CBVCTBI with high resolution volume of interest (VOI) reconstruction mode for target imaging, will also better characterize breast tumors three-dimensionally; conventional mammography does not provide 3D information of breast cancer. CBVCTBI will be developed and validated through computer simulation, phantom and specimen studies performed on a specially designed DBVCTBI prototype system that uses a flat panel detector (FPD) and cone beam tomographic acquisition geometry. This is an R21-R33 combined project. Specific aims of the R21project include: 1) Perform phantom studies to determine the required total exposure level (absorbed patient dose) for breast cancer imaging task, 2) Implement and optimize a fast cone beam reconstruction algorithm on a dual processor PC workstation, 3) Perform a comparison study of breast coverage near the chest wall between a conventional mammography system and a slightly modified standard stereotactic biopsy table (which will be used for the prototype CBVCTBI scanner) to provide evidence for appropriate coverage of the breast near the chest wall. 4) Obtain institutional review boar (IRB) approval to image breast specimens in the R33 project period. Specific aims for the R33 project period include: 1) Estimate glandular radiation dose for CBVCTBI technique, 2) Implement and optimize the cone beam reconstruction algorithms based on the different new volume scan schemes, 3) Develop the FPD-based prototype system, 4) Evaluate the prototype system, 5) Perform phantom and specimen studies to validate the CBVCTBI technique and optimize the system performance.

描述（由申请人提供）：该项目的长期目标是开发一种新型锥形束体积计算机断层扫描乳腺成像（CBVCTBI）技术，为乳腺癌检测提供临床有用的三维（3D）高分辨率断层扫描图像。 CBVCTBI 只需要一次快速体积扫描（4.8-9.6 秒）即可以 2.0-5.0 1p/mm 各向同性分辨率提供乳腺解剖结构的真实 3D 描述，并将为乳腺癌检测提供足够的低对比度分辨率和高对比度空间分辨率。 CBVCTBI 的临床意义在于，与相比，CBVCTBI 具有更好的低对比度分辨率，因此将提高乳腺癌检测的灵敏度。 到传统的乳房X光检查。 CBVCTBI采用高分辨率感兴趣体积（VOI）重建模式进行目标成像，也将更好地表征乳腺肿瘤的三维特征；传统的乳房 X 光检查无法提供乳腺癌的 3D 信息。 CBVCTBI 将通过在专门设计的 DBVCTBI 原型系统上进行的计算机模拟、体模和样本研究来开发和验证，该原型系统使用平板探测器 (FPD) 和锥形束断层扫描采集几何结构。 这是一个R21-R33组合项目。 R21项目的具体目标包括：1) 进行模型研究以确定乳腺癌成像任务所需的总暴露水平（患者吸收剂量），2) 在双处理器 PC 工作站上实施和优化快速锥形束重建算法，3) 对传统乳房 X 线摄影系统和稍作修改的标准立体定向活检台（将用于 原型 CBVCTBI 扫描仪）为适当覆盖靠近胸壁的乳房提供证据。 4) 获得机构审查公猪 (IRB) 批准，在 R33 项目期间对乳腺标本进行成像。 R33项目期间的具体目标包括：1）估计CBVCTBI技术的腺体辐射剂量，2）基于不同的新体积扫描方案实施和优化锥束重建算法，3）开发基于FPD的原型系统，4）评估原型系统，5）进行体模和标本研究以验证CBVCTBI技术并优化系统性能。