High resolution cone beam volume CT for breast imaging

用于乳腺成像的高分辨率锥形束体积 CT

• 批准号: 7082212
• 负责人: RUOLA NING
• 金额: $ 58.57万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-03 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7082212
• 关键词: X ray; bioimaging /biomedical imaging; breast neoplasm /cancer diagnosis; clinical research; computed axial tomography; early diagnosis; female; human subject; image enhancement; mammography; phantom model; radiation dosage; technology /technique development; three dimensional imaging /topography; women' s health

DESCRIPTION (provided by applicant): The long term goal of this project is to develop a novel cone beam volume computed tomography breast imaging (CBVCTBI) technique to provide clinically useful three-dimensional (3D) high resolution tomographic images for breast cancer detection. CBVCTBI will require only a single fast volume scanning (4.8-9.6 seconds) to provide true 3D description of breast anatomy with 2.0-5.0 1p/mm isotropic resolution and will provide adequate low contrast resolution and high contrast spatial resolution for breast cancer detection.The clinical significance of CBVCTBI is that it will improve the sensitivity of breast cancer detection due to its much better low contrast resolution, compared to conventional mammography. CBVCTBI with high resolution volume of interest (VOI) reconstruction mode for target imaging, will also better characterize breast tumors three-dimensionally; conventional mammography does not provide 3D information of breast cancer. CBVCTBI will be developed and validated through computer simulation, phantom and specimen studies performed on a specially designed DBVCTBI prototype system that uses a flat panel detector (FPD) and cone beam tomographic acquisition geometry. This is an R21-R33 combined project. Specific aims of the R21project include: 1) Perform phantom studies to determine the required total exposure level (absorbed patient dose) for breast cancer imaging task, 2) Implement and optimize a fast cone beam reconstruction algorithm on a dual processor PC workstation, 3) Perform a comparison study of breast coverage near the chest wall between a conventional mammography system and a slightly modified standard stereotactic biopsy table (which will be used for the prototype CBVCTBI scanner) to provide evidence for appropriate coverage of the breast near the chest wall. 4) Obtain institutional review boar (IRB) approval to image breast specimens in the R33 project period. Specific aims for the R33 project period include: 1) Estimate glandular radiation dose for CBVCTBI technique, 2) Implement and optimize the cone beam reconstruction algorithms based on the different new volume scan schemes, 3) Develop the FPD-based prototype system, 4) Evaluate the prototype system, 5) Perform phantom and specimen studies to validate the CBVCTBI technique and optimize the system performance.

描述（由申请人提供）：该项目的长期目标是发展一种新的锥束体积计算机断层扫描乳房成像（CBVCTBI）技术，为乳腺癌检测提供临床有用的三维（3D）高分辨率断层成像图像。CBVCTBI将只需要一次快速体积扫描（4.8-9.6秒），以2.0-5.0 1p/mm各向同性分辨率提供乳腺解剖的真实3D描述，并将为乳腺癌检测提供足够的低对比度分辨率和高对比度空间分辨率。CBVCTBI的临床意义在于，与常规乳房x线摄影相比，它具有更好的低对比度分辨率，将提高乳腺癌检测的敏感性。CBVCTBI采用高分辨率感兴趣体积（VOI）重建模式进行靶成像，也能更好地对乳腺肿瘤进行三维表征；传统的乳房x光检查不能提供乳腺癌的三维信息。CBVCTBI将通过计算机模拟、模型和样本研究进行开发和验证，该系统采用平板探测器（FPD）和锥形束层析成像采集几何结构，是一个专门设计的DBVCTBI原型系统。这是一个R21-R33组合项目。r21计划的具体目标包括：1)进行幻体研究以确定乳腺癌成像任务所需的总照射水平（患者吸收剂量）；2)在双处理器PC工作站上实现并优化快速锥束重建算法；3)对常规乳房x线摄影系统与稍作改进的标准立体定向活检台（CBVCTBI原型机将使用该标准立体定向活检台）进行胸壁附近乳房覆盖的对比研究，为胸壁附近乳房的适当覆盖提供依据。4)获得机构审查委员会（IRB）批准，在R33项目期间对乳房标本进行成像。R33项目期间的具体目标包括：1)估算CBVCTBI技术的腺体辐射剂量；2)实施和优化基于不同新体积扫描方案的锥束重建算法；3)开发基于fpd的原型系统；4)评估原型系统；5)进行模型和标本研究以验证CBVCTBI技术并优化系统性能。