THREE DIMENSIONAL TOMOGRAPHIC ANGIOGRAPHY

描述：确定哪些患者将受益于特定的 治疗过程需要对严重程度的准确评估 狭窄、它们的几何形状和空间方向。最具治疗作用 目前的决策是基于通过数字方式获得的信息 减影血管造影术。标准的血管造影术图像不提供 血管造影师需要足够的信息来进行治疗 决定。 这项为期四年的计划的长期目标是不断开发一种 三维(3D)层析成像(称为体积层析成像)数字 血管造影成像技术以提供所需的有用的3-D血管图像 用于诊断和治疗决策。 体积断层数字血管造影术(VTDA)结合体积断层成像 成像原理与数字血管造影术的原理相同。VTDA只需要一个 单次静脉注射造影剂和容量扫描提供真正的 描述头部和颈部的血管解剖和狭窄。 这种VTDA技术将优于传统的血管造影术，并具有 强大的临床影响，因为它将提供直接、明确和 精确的狭窄和其他不规则的三维测量和 畸形，包括口径、几何形状和空间方位，而 减少手术的侵袭性，减少造影剂的用量 所需时间、手术时间和总X射线曝光量。 VTDA继续通过计算机模拟来开发和验证， Phantom和在旋转体积断层扫描上进行的动物研究 使用硒薄膜晶体管(STFT)阵列或图像的成像器 增强器(II)，耦合到电荷耦合器件(CCD)作为探测器。 具体地说，拟议研究的目的是：1)研究 VTDA的计算机模拟优化；2)锥形束的优化 血管重建算法；3)使用升级的基于II的VTDA系统 开发和评估新的扫描模式，开发基于短时傅立叶变换的 最终静脉注射造影剂的原型成像系统；4)至 执行模型研究以验证VTDA技术并优化 系统性能；5)动物样机的使用 作为人体研究的前奏的实验；以及6)进行临床 基于最优注射量和注射量的颈、脑研究 在动物研究中开发的扫描方案。

DESCRIPTION: Identification of patients who will benefit from a specific therapeutic procedure requires the accurate assessment of the severity of stenoses, their geometry and spatial orientation. Most therapeutic decisions are currently based on information obtained through digital subtraction angiography. Standard angiographic images are not providing angiographers with sufficient information needed to make therapeutic decisions. The long-term goal of this four year project is to continually develop a three-dimensional (3-D) tomographic (called volume tomographic) digital angiography imaging technique to provide useful 3-D vascular images needed for diagnostic and therapeutic decisions. Volume tomographic digital angiography (VTDA) combines volume tomographic imaging principles with those of digital angiography. VTDA requires only a single intravenous contrast injection and volume scan to provide a true description of vascular anatomy and stenoses in head and neck. This VTDA technique will be superior to conventional angiography and have a strong clinical impact because it will provide a direct, unambiguous and accurate 3D measurement of stenoses and other irregularities and malformations, including caliber, geometry and spatial orientation, while reducing the invasiveness of the procedure, the amount of contrast media required, procedure time and total X-ray exposure. VTDA continues to be developed and validated through computer simulation, phantom, and animal studies performed on a rotational volume tomographic imager that uses a selenium thin film transistor (STFT) array or an image intensifier (II) coupled to a charge-coupled device (CCD) as a detector. Specifically, the aim of the proposed research is: 1) to perform studies on optimization of VTDA through computer simulation; 2) to optimize cone beam vascular reconstruction algorithms; 3) use the upgraded II-based VTDA system to develop and evaluate new scanning modes and develop the STFT-based prototype imaging system for ultimate intravenous contrast injection; 4) to perform phantom studies to validate the VTDA technique and optimize the system performance; and 5) to use the prototype imager for animal experiments as a prelude to human studies; and 6) to perform the clinical studies in neck and brain based on the optimized injection and volume scanning protocols developed in animal studies.