FLAT PANEL DETECTOR BASED CONE BEAM VOLUME CT

基于平板探测器的锥束体积 CT

• 批准号: 6497993
• 负责人: RUOLA NING
• 金额: $ 45.3万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6497993
• 关键词: bioimaging /biomedical imaging; calcium; computed axial tomography; computer simulation; diagnosis design /evaluation; lung neoplasms; method development; neoplasm /cancer radiodiagnosis; phantom model; postmortem; radiation detector

DESCRIPTION (Verbatim from Applicant's Abstract): The long term goal of this project is to develop a high resolution cone beam volume computed tomography (CBVCT) imaging technique to provide clinically useful three-dimensional (3D) high resolution images for thoracic oncologic imaging. CBVCT uses a cone beam geometry and a newly developed digital flat panel detector for fast volume scanning. It will require only a single fast volume scanning (2 - 8.0 seconds) to provide true 3D description of pulmonary anatomy with 0.7 - 4.0 lp/mm isotropic resolution. CBVCT represents the next step in the evolution in CT. Rapid acquisition will eliminate most motion artifacts. Sub-millimeter isotropic resolution should detect more pulmonary nodules, virtually eliminating partial volume average artifacts. CBVCT should allow for the first time accurate determination of size, growth, density, and enhancement characteristics of small pulmonary nodules. This would be a major advance in oncologic pulmonary imaging. CBVCT will be developed and validated through computer simulation, phantom and animal studies performed on a prototype imaging system that uses a thin film transistor (TFT) flat panel detector and cone beam tomographic acquisition geometry. Specifically, the aims of the proposed research are: 1) Develop and validate data acquisition technique for TFT array-based CBVCT through computer simulation, 2) Develop, implement and optimize the cone beam reconstruction algorithms, 3) Construct a TFT-based prototype CBVCT scanner, 4) Test and optimize the CBVCT technique through phantom studies, and 5) Evaluate imaging performance of the CBVCT system through comparison phantom studies with a multi-slice CT. Animal studies will be prepared upon the successful completion of this proposed research.

描述（申请人摘要逐字记录）：本项目的长期目标 项目是开发高分辨率锥形束体积计算机断层扫描 (CBVCT) 成像技术，提供临床上有用的三维 (3D) 用于胸部肿瘤成像的高分辨率图像。 CBVCT 采用锥束几何结构和新开发的数字平板 用于快速体积扫描的探测器。只需要一个快速卷 扫描（2 - 8.0 秒）以提供肺部解剖结构的真实 3D 描述 各向同性分辨率为 0.7 - 4.0 lp/mm。 CBVCT 代表了 CT 发展的下一步。快速收购将 消除大多数运动伪影。 亚毫米各向同性分辨率应该可以检测到更多的肺部结节， 几乎消除了部分体积平均伪影。 CBVCT 应允许 首次准确测定尺寸、生长、密度和增强 肺部小结节的特点。这将是一个重大进步 肿瘤肺部成像。 CBVCT 将通过计算机模拟、模型和 在使用薄膜的原型成像系统上进行的动物研究 晶体管 (TFT) 平板探测器和锥束断层扫描采集 几何学。具体来说，拟议研究的目标是：1）开发和 通过计算机验证基于 TFT 阵列的 CBVCT 数据采集技术 仿真，2) 开发、实施和优化锥束重建 算法，3) 构建基于 TFT 的原型 CBVCT 扫描仪，4) 测试和 通过模型研究优化 CBVCT 技术，以及 5) 评估成像 通过与模型比较研究来评估 CBVCT 系统的性能 多层CT。 动物研究将在成功完成本提议后准备 研究。