How amyloid causes neurodegeneration: the role of transthyretin in familial amyloidotic polyneuropathy

淀粉样蛋白如何引起神经变性：运甲状腺素蛋白在家族性淀粉样变性多发性神经病中的作用

• 批准号: nhmrc : 544920
• 负责人: Dr Harold Coleman
• 金额: $ 41.27万
• 依托单位: Menzies Institute for Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/amyloid-causes-neurodegeneration-amyloidotic-polyneuropathy/97287
• 关键词: How; amyloid; causes; neurodegeneration; role

This project seeks to understand the biochemical basis of nerve degeneration in a disease known as familial amyloidotic polyneuropathy. This disease is caused by a protein known as transthyretin, which is abnormally deposited around nerves and causes nerve damage. The project is highly likely to provide clues which help us understand some related dementia causing diseases like Alzheimer's disease and prion diseases such as scrapie and mad cow disease.

该项目旨在了解一种称为家族性淀粉样多发性神经病的神经变性的生化基础。这种疾病是由一种被称为甲状腺素运载蛋白的蛋白质引起的，这种蛋白质异常地沉积在神经周围并导致神经损伤。该项目很有可能提供线索，帮助我们了解一些相关的痴呆症引起的疾病，如阿尔茨海默氏症和朊病毒疾病，如羊瘙痒症和疯牛病。