TRANSLATIONAL RESEARCH AND SCIENCE EDUCATION

转化研究和科学教育

• 批准号: 6739301
• 负责人: TING-KAI K LI
• 金额: $ 19.52万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6739301
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; alcoholism /alcohol abuse education; behavioral /social science research tag; behavioral genetics; genetic susceptibility; health science research support

DESCRIPTION (provided by applicant): This component of the IARC competing renewal application qualifies the IARC for potential designation and funding as a Comprehensive Center (P60). The overall objective of the component is to advance alcohol research and its dissemination for the purpose of improving the treatment of alcohol-affected individuals and the prevention of alcohol-related problems. This will be accomplished through: (a) collaborative research partnerships with other institutions, especially minority and minority-serving institutions; (b) sponsoring and organizing the biennial scientific conference for pre- and post-doctoral fellows and young investigators; (c) continuing education opportunities to treatment professionals in clinical settings and to the community at large, especially those in the judiciary, administrative and legislative branches of State government; (d) the clinical teaching of the diagnosis and treatment of alcohol and drug abuse and dependence for (3rd year) medical students, and extension of the educational base to masters degree level students in the IU School of Social Work; (e) the Bench to Bench Program of Science Education in Alcohol Problems for Indiana Judges. These activities will draw upon the expertise of the IARC-affiliated faculty at Indiana and Purdue Universities that reflect the broadly-based research theme of the center's research programs: a) The genetic determinants of alcohol ingestive behavior and other responses to alcohol, b) The interplay of genetic, behavioral and social risk factors in the etiology of alcoholism, c) The neurobiological basis of alcohol addiction as manifested by craving, loss of control drinking, and relapse, which will serve as the basis for rational pharmacotherapeutic interventions, d) The intimate interaction of the pharmacokinetics of alcohol with its pharmacodynamic actions and how individual variability in both these domains influence susceptibility to problem and dependent drinking.

描述（由申请人提供）：IARC竞争更新申请的这一组成部分使IARC有资格获得作为综合中心（P60）的潜在指定和资助。这一部分的总体目标是推动酒精问题的研究及其传播，以改善对受酒精影响的个人的治疗和预防与酒精有关的问题。这将通过以下方式实现：（a）与其他机构，特别是少数群体和为少数群体服务的机构建立合作研究伙伴关系;（B）为博士前和博士后研究员和年轻研究人员赞助和组织两年一次的科学会议;为临床治疗专业人员和广大社区，特别是司法部门的专业人员提供继续教育的机会，州政府行政和立法部门;（d）酒精和药物滥用和依赖诊断和治疗的临床教学（第三年） 医学生，并将教育基础扩展到印第安纳大学社会工作学院的硕士学位水平学生;（e）印第安纳州法官酒精问题的法官对法官科学教育计划。这些活动将利用印第安纳州和普渡大学的IARC附属教师的专业知识，反映该中心研究计划的广泛研究主题：a）酒精摄入行为和对酒精的其他反应的遗传决定因素，B）遗传、行为和社会风险因素在酒精中毒病因学中的相互作用，c）酒精成瘾的神经生物学基础，表现为渴望、饮酒失控和复发，这将作为合理药物干预的基础，d）酒精的药代动力学与其药效学作用的密切相互作用，以及这两个领域的个体差异如何影响对问题和依赖性饮酒的易感性。