Photoacoustic imaging for the optimisation of CAR-T cell cancer therapy of soft-tissue tumours A metrology and system development

用于优化软组织肿瘤 CAR-T 细胞癌症治疗的光声成像计量学和系统开发

• 批准号: 2596279
• 金额: --
• 依托单位: University of Surrey
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2596279
• 关键词: Photoacoustic; imaging; optimisation; CAR; cell

This project aims to develop and evaluate the use of photoacoustic imaging for determining the biodistribution of the CAR-T cells in vivo. The project objectives include: development of methodologies for photoacoustic quantification of tumour and/or CAR-T cell numbers and assessment of their performance in tissue-mimicking phantoms;validating the methods for cell number quantification in vivo; exploring the application to the dynamic quantification of CAR-T cell numbers as they penetrate tumours; evaluating alternative ultrasound array configurations and noise reduction methods to improve performance for CAR-T cell tracking in vivo

该项目旨在开发和评估光声成像用于确定CAR-T细胞在体内的生物分布。项目目标包括：开发肿瘤和/或CAR-T细胞数量的光声定量方法，并评估其在组织模拟体模中的性能;验证体内细胞数量定量方法;探索CAR-T细胞穿透肿瘤时动态定量CAR-T细胞数量的应用;评估替代超声阵列配置和降噪方法，以提高体内CAR-T细胞跟踪的性能