Northeastern Ohio Animal Imaging Resource Center- NOAIRC

俄亥俄州东北部动物成像资源中心 - NOAIRC

• 批准号: 6941357
• 负责人: JEFFREY L. DUERK
• 金额: $ 68.09万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941357
• 关键词: bioimaging /biomedical imaging; bioluminescence; biomedical resource; computed axial tomography; magnetic resonance imaging; molecular /cellular imaging; neoplasm /cancer radiodiagnosis; optical tomography; positron emission tomography; single photon emission computed tomography; spectrometry

DESCRIPTION (provided by applicant): We propose to form the Northeastern Ohio Animal Imaging Resource Center (NOAIRC) to provide the many regional cancer researchers with state-of-the-art small animal, molecular and cellular imaging facilities and expertise. Systems will include a combined micro-X-ray computed tomography/SPECT system, a clinical SPECT system with pin-hole collimators, a high resolution micro-PET system, and 7T and 9.4T small animal MR imaging and spectroscopy systems. All are already on-site or ordered from recent grant awards and institutional sources. With an SAIRP award, we will acquire a bioluminescence/fluorescence imaging system to facilitate reporter gene methods and new opportunities in novel agents (e.g., quantum dots). We will also create small animal optical coherence tomography with color Doppler and microscopic OCT to promote in vivo spectroscopic methods and high spatial and temporal analysis of structure and function (e.g., perfusion). Interdisciplinary backing for this project is unprecedented with financial and other commitments from three schools of Case Western Reserve University (Medicine, Engineering, Arts & Sciences), the University Hospitals of Cleveland, the Case Comprehensive Cancer Center, and the State of Ohio. In addition to core resources via nuclear imaging, MR imaging and spectroscopy, bioluminescence/fluorescence, and OCT, the NOAIRC will also provide an integrated environment with core facilities in quantitative image analysis and visualization, animal welfare/experiment preparation and novel imaging agents like functionalized liposomes or CEST agents. This latter core integrates with our radionuclide imaging capabilities, our ongoing biomolecular and nanoscale engineering for targeted therapeutics initiative, ongoing research in reporter genes, and a P20 In-vivo and Molecular Imaging Center planning grant to add strategic strength in molecular imaging. All of these will be within a single facility to promote cross-collaboration and interdisciplinary research. This proposal brings together researchers in imaging with the many regional scientists who are studying cancer biology via small animal models and rapidly gaining an appreciation of the power of in vivo imaging. We aim to advance small animal imaging technology by developing new image acquisition and analysis methods, new methods in reporter genes and functionalized agents, and pharmacokinetic modeling. We will apply developments to experiments in cancer biology and therapy. Animal welfare/preparation research will focus on analysis of physiologic effects of anesthesia and developing new formulations that maintain the physiology to be measured, while providing state-of-the-art methods for blood sampling and monitoring. The NOAIRC will include a strong educational focus to create a long-range impact. It will invigorate strong Ph.D. programs in imaging already at Case. It will strengthen educational programs for basic and clinical scientists in cancer via integration with existing T32 and K12 grants and promote new horizons via K25 proposals. The result will be clinicians, scientists, and engineers trained for the next generation of conventional and molecular imaging techniques.

描述（由申请人提供）：我们建议成立俄亥俄州东北部动物成像资源中心（NOAIRC），为许多地区癌症研究人员提供最先进的小动物、分子和细胞成像设施和专业知识。系统将包括组合式微型 X 射线计算机断层扫描/SPECT 系统、带针孔准直器的临床 SPECT 系统、高分辨率微型 PET 系统以及 7T 和 9.4T 小动物 MR 成像和光谱系统。所有这些都已在现场或从最近的拨款和机构来源订购。凭借 SAIRP 奖项，我们将获得生物发光/荧光成像系统，以促进报告基因方法和新型药物（例如量子点）的新机遇。我们还将利用彩色多普勒和显微 OCT 创建小动物光学相干断层扫描，以促进体内光谱方法以及结构和功能（例如灌注）的高时空分析。 该项目的跨学科支持是前所未有的，来自凯斯西储大学三所学院（医学、工程、艺术与科学）、克利夫兰大学医院、凯斯综合癌症中心和俄亥俄州的财政和其他承诺。除了核成像、磁共振成像和光谱学、生物发光/荧光和 OCT 等核心资源外，NOAIRC 还将提供一个集成环境，其中包括定量图像分析和可视化、动物福利/实验准备以及功能化脂质体或 CEST 剂等新型成像剂等核心设施。后一个核心与我们的放射性核素成像能力、我们正在进行的靶向治疗计划的生物分子和纳米级工程、正在进行的报告基因研究以及 P20 体内和分子成像中心计划拨款相结合，以增加分子成像方面的战略实力。所有这些都将在一个设施内进行，以促进交叉合作和跨学科研究。 该提案将成像领域的研究人员与许多地区科学家聚集在一起，他们正在通过小动物模型研究癌症生物学，并迅速认识到体内成像的力量。我们的目标是通过开发新的图像采集和分析方法、报告基因和功能化药物的新方法以及药代动力学模型来推进小动物成像技术。我们将把这些进展应用于癌症生物学和治疗的实验。动物福利/准备研究将重点分析麻醉的生理效应，开发维持待测生理学的新配方，同时提供最先进的血液采样和监测方法。 NOAIRC 将重点关注教育，以产生长期影响。它将激发强大的博士学位。凯斯已经有成像项目。它将通过与现有的 T32 和 K12 拨款相结合，加强癌症基础和临床科学家的教育计划，并通过 K25 提案促进新视野。其结果将是临床医生、科学家和工程师接受下一代传统和分子成像技术的培训。