Northeastern Ohio Animal Imaging Resource Center- NOAIRC

俄亥俄州东北部动物成像资源中心 - NOAIRC

• 批准号: 6941357
• 负责人: JEFFREY L. DUERK
• 金额: $ 68.09万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941357
• 关键词: bioimaging /biomedical imaging; bioluminescence; biomedical resource; computed axial tomography; magnetic resonance imaging; molecular /cellular imaging; neoplasm /cancer radiodiagnosis; optical tomography; positron emission tomography; single photon emission computed tomography; spectrometry

DESCRIPTION (provided by applicant): We propose to form the Northeastern Ohio Animal Imaging Resource Center (NOAIRC) to provide the many regional cancer researchers with state-of-the-art small animal, molecular and cellular imaging facilities and expertise. Systems will include a combined micro-X-ray computed tomography/SPECT system, a clinical SPECT system with pin-hole collimators, a high resolution micro-PET system, and 7T and 9.4T small animal MR imaging and spectroscopy systems. All are already on-site or ordered from recent grant awards and institutional sources. With an SAIRP award, we will acquire a bioluminescence/fluorescence imaging system to facilitate reporter gene methods and new opportunities in novel agents (e.g., quantum dots). We will also create small animal optical coherence tomography with color Doppler and microscopic OCT to promote in vivo spectroscopic methods and high spatial and temporal analysis of structure and function (e.g., perfusion). Interdisciplinary backing for this project is unprecedented with financial and other commitments from three schools of Case Western Reserve University (Medicine, Engineering, Arts & Sciences), the University Hospitals of Cleveland, the Case Comprehensive Cancer Center, and the State of Ohio. In addition to core resources via nuclear imaging, MR imaging and spectroscopy, bioluminescence/fluorescence, and OCT, the NOAIRC will also provide an integrated environment with core facilities in quantitative image analysis and visualization, animal welfare/experiment preparation and novel imaging agents like functionalized liposomes or CEST agents. This latter core integrates with our radionuclide imaging capabilities, our ongoing biomolecular and nanoscale engineering for targeted therapeutics initiative, ongoing research in reporter genes, and a P20 In-vivo and Molecular Imaging Center planning grant to add strategic strength in molecular imaging. All of these will be within a single facility to promote cross-collaboration and interdisciplinary research. This proposal brings together researchers in imaging with the many regional scientists who are studying cancer biology via small animal models and rapidly gaining an appreciation of the power of in vivo imaging. We aim to advance small animal imaging technology by developing new image acquisition and analysis methods, new methods in reporter genes and functionalized agents, and pharmacokinetic modeling. We will apply developments to experiments in cancer biology and therapy. Animal welfare/preparation research will focus on analysis of physiologic effects of anesthesia and developing new formulations that maintain the physiology to be measured, while providing state-of-the-art methods for blood sampling and monitoring. The NOAIRC will include a strong educational focus to create a long-range impact. It will invigorate strong Ph.D. programs in imaging already at Case. It will strengthen educational programs for basic and clinical scientists in cancer via integration with existing T32 and K12 grants and promote new horizons via K25 proposals. The result will be clinicians, scientists, and engineers trained for the next generation of conventional and molecular imaging techniques.

描述（由申请人提供）：我们建议组建俄亥俄州东北动物成像资源中心（NOAIRC），以向许多地区癌症研究人员提供最新的小动物，分子和细胞成像设施和专业知识。系统将包括一个组合的Micro-X射线计算机断层扫描/SPECT系统，具有针孔准直晶石器的临床SPECT系统，高分辨率的微型PET系统以及7T和9.4T小动物MR成像和光谱系统。所有这些都已是现场或从最近的赠款奖和机构来源订购的。通过SAIRP奖，我们将获得生物发光/荧光成像系统，以促进记者基因方法和新型药物的新机会（例如量子点）。我们还将与颜色多普勒和微观OCT创建小动物光学相干断层扫描，以促进体内光谱方法以及对结构和功能的高空间和时间分析（例如，灌注）。 该项目的跨学科支持是前所未有的，包括三所凯斯西部储备大学（医学，工程，艺术与科学），克利夫兰大学医院，案例综合癌症中心和俄亥俄州的财务和其他承诺。除了通过核成像，MR成像和光谱，生物发光/荧光和OCT的核心资源外，Noairc还将提供一个集成的环境，并具有定量图像分析和可视化，动物福利/实验制备以及功能化脂质体或CEST药物等新型成像剂的核心设施。后一个核心与我们的放射性核素成像能力，我们正在进行的生物分子和纳米级工程针对有针对性的治疗倡议，报道基因的持续研究以及P20 In-Vivo和Molecular Imaging Center Planning授予，以在分子成像中增加策略性强度。所有这些都将在一个设施中，以促进跨学科和跨学科研究。 该建议将研究人员与许多正在通过小动物模型研究癌症生物学研究的区域科学家进行成像，并迅速欣赏体内成像的力量。我们旨在通过开发新的图像获取和分析方法，报告基因和功能化剂的新方法以及药代动力学建模来推进小型动物成像技术。我们将把发展应用于癌症生物学和治疗的实验。动物福利/制备研究将集中于分析麻醉的生理效应，并开发新的制剂，以维护要测量的生理学，同时提供最新的血液采样和监测方法。 Noairc将包括强大的教育重点，以产生远距离影响。它将激发强大的博士学位。成像的程序已经在情况下。它将通过与现有的T32和K12赠款的一体化并通过K25提案来加强癌症基础和临床科学家的教育计划。结果将是临床医生，科学家和工程师接受了下一代常规和分子成像技术的培训。