Improvements in Spiral MR Imaging

螺旋磁共振成像的改进

• 批准号: 7119213
• 负责人: JEFFREY L. DUERK
• 金额: $ 40.73万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7119213
• 关键词: abdomen; adipose tissue; bioimaging /biomedical imaging; brain imaging /visualization /scanning; clinical research; computer program /software; computer simulation; evaluation /testing; functional magnetic resonance imaging; heart imaging /visualization /scanning; human subject; image enhancement; image processing; magnetic resonance imaging

DESCRIPTION (provided by applicant): Using a state-of-the-art 1.5T MR system, the main goal of the proposed project is to create significant im- provements in spiral MRI via novel techniques that reduce imaging time, improve immunity to motion artifact, and improve off-resonance (and chemical shift) reconstruction so that new and/or improved cardiac, brain and body imaging applications will be enabled. The specific aims are to: (1) improve spiral MR motion artifact immunity by developing efficient reductions in spiral MRI acquisition time through parallel imaging methods and reconstruction (e.g., SENSE, GRAPPA, conjugate gradient) at high acceleration; (2) develop new rapid off-resonance correction techniques with improved performance and reduced computation time when compared to conventional frequency segmented methods, (3) create robust spiral fat/water separation methods that prevent off-resonance blurring and provide superior performance and reduced acquisition time when compared to spatial spectral techniques, and, (4) develop methodologies for Pareto-optimal /(-space trajectory design based on minimizing time, aliasing energy, flow sensitivity, off-resonance blurring and/or other image quality measurements. Our project will show that use of new spiral acquisition, new post-processing methods and new trajectory de- sign techniques using/(-space and/or image data can reduce imaging time and significantly improve cardiac, brain and abdominal imaging. Preliminary results show that significant improvements in motion immunity through parallel imaging are possible. Significant work remains to explore improvements in reconstruction algorithms, amount of acceleration, and reliability. Off-resonance computational burden can be reduced by using a block re- gional correction method. For example, further improvements in performance and speed will explore use of re- gional information to control the computational block size. Our fat suppression methods will give rise to reductions in scan time by up to a factor of 2-4X with superior performance as compared to commonly used spatial spectral approaches; the efficiency/robustness of 2pt and 3pt Spiral Dixon methods (at equal scan time) are explored. These alone will enable improved abdominal and cardiac imaging when compared to conventional rectilinear or spiral methods. Uniquely, our advanced non-rectilinear trajectory, design method is that the inter-relationship be- tween off-resonance, motion and kappa-space sampling density effects are formally linked to image domain artifacts, thereby enabling unique waveform parameterizations and formal optimization to create superior trajectories (and hence better images) than those designed conventionally. We believe successful attainment of these aims will give rise to significant improvements in spiral MR and hence greater utilization of this important MR method.

描述（由申请人提供）：使用最先进的1.5T MR系统，拟议项目的主要目标是通过减少成像时间，改善对运动伪像的免疫力并改善异位（和化学转移）重建的螺旋性MRI的重大证明，从而使新的和/或改善心脏或改善心脏的心脏和身体成像。具体的目的是：（1）通过高加速度以平行成像方法和重建（例如，有义务，grappa，结合梯度）来发展有效减少螺旋MRI获取时间来改善螺旋MR运动伪影免疫。 （2）与常规频率分段方法相比，开发新的快速振荡校正技术，并提高了性能和减少的计算时间，（3）创建强大的螺旋脂肪 /水分分离方法，以防止差异模糊，并在空间频谱技术上进行较小的方法，（4）与帕特尔（4）相比，（4）（4）（4）（4）（4），（4）时间，混叠能量，流动敏感性，异源模糊和/或其他图像质量测量。 我们的项目将表明，使用/（ - 空间和/或图像数据可以减少成像时间，并显着改善心脏，大脑和腹部成像的新型螺旋式获取，新的后处理方法以及新的轨迹技术。初步结果可以显着改善心脏和腹部成像的结果。通过平行成像进行了重要的运动免疫，可以探索重新构建的量子，以及重新构建的重新构建量，并在重新构建中构建阶层，并构建了累加的范围。通过使用块校正方法可以减少呼气，例如，性能的进一步改善将探索使用信息的使用，以控制我们的脂肪抑制方法，从而在扫描时间中降低了2-4x的效果。 （在相等的扫描时间）与常规的直线或螺旋方法相比，仅这些单独的扫描时间可以改善腹部和心脏成像。独特的是，我们先进的非电线轨迹的设计方法是，与图像域伪像之间的相互关联，运动和Kappa空间采样密度效应之间的相互关系与图像域伪像，从而启用了独特的波浪形参数和形式优化，以创建出色的轨迹（以及更高的图像）。我们认为，成功实现这些目标将导致螺旋MR的显着改善，从而更大程度地利用了这种重要的MR方法。