NEW FACULTY RECRUITMENT IMAGE-GUIDED CANCER THERAPEUTICS

描述(由申请人提供)：凯斯西储大学(CWRU)生物医学工程系(BME)将转化研究、纳米技术以及生物医学和放射成像的发展视为其愿景和使命的一部分。通过招聘一名终身教职助理教授，我们试图通过利用纳米粒子制造中的纳米级控制来设计多功能试剂，促进癌症治疗的诊断、治疗和监测，从而研究“图像引导癌症治疗”。今天的癌症治疗方法采取的是“一刀切”的剂量和给药方法，必须探索新的改进的治疗策略，将拼图中的技术片段结合起来，从而产生定制的、针对患者的治疗策略。具体地说，我们建议招聘一名终身教职员工，以帮助CWRU统一工程、成像和癌症方面的全方位专业知识。这样的计划将利用BME部门、病例成像研究中心、医学院和病例综合癌症中心的药物输送、纳米技术和成像组件的现有优势，以及医学院和病例综合癌症中心的一流医学和基础研究，开发一个高度协作的计划，旨在通过非侵入性询问肿瘤血管状态，以患者特有的方式促进新型成像工具的临床翻译和开发，以实现改进的治疗。为了实现这些目标，该计划将利用包括硅胶、体外和体内研究在内的工程方法。重要的是，这些工具可以作为其他疾病的平台技术，在这些疾病中，血管状态和完整性的知识非常重要(例如动脉粥样硬化、缺血)。拟议计划的目标是开发可翻译的和临床相关的成像技术，这些技术可以非侵入性地检测和监测(1)癌症状态和(2)以患者特有的方式预测和监测抗癌药物的效果。该计划将进一步促进俄亥俄州快速增长的纳米技术、癌症治疗和成像以及医疗行业。除了对医疗保健的重大影响外，该计划还可能促进创造就业机会和对俄亥俄州的长期经济影响。 与公共健康相关(由申请者提供)：今天的癌症治疗方法采用的是“一刀切”的方法，必须探索新的改进的、可定制的治疗方法。通过招聘一名助理教授，该计划旨在将纳米技术与临床相关的成像技术相结合，以患者特有的方式提供治疗的预后和监测工具，使肿瘤学家能够更好地选择不同的治疗方案。

DESCRIPTION (provided by applicant): The Department of Biomedical Engineering (BME) at Case Western Reserve University (CWRU) views translational research, nanotechnology, and development of biomedical and radiologic imaging as part of its vision and mission. Via the recruitment of a tenure-track Assistant Professor, we seek to investigate "Image-Guided Cancer Therapeutics" by exploiting the nanoscale control in fabricating nanoparticles to design multifunctional agents that facilitate diagnosing, treating and monitoring of cancer therapies. Today's cancer therapeutics take a 'one-size-fits-all' approach to dosage and delivery of drugs, and new improved therapeutic strategies have to be explored that incorporate the technological pieces of a puzzle that can lead to customized, patient-specific therapeutic strategies. Specifically, we propose to recruit a tenure track faculty member to help unite the full spectrum of engineering, imaging and cancer expertise at CWRU. Such a program will exploit the existing strengths of the drug delivery, nanotechnology and imaging components of the BME Department, Case Center for Imaging Research, and the superb medical and basic research occurring at the School of Medicine, and the Case Comprehensive Cancer Center to develop an extremely collaborative program aimed at clinical translation and development of novel imaging tools as enablers of improved therapies in a patient-specific manner via non-invasive interrogation of tumor vasculature status. To achieve these goals, the program will utilize engineering approaches including in silico, in vitro and in vivo studies. Importantly, these tools can serve as platform technologies for other diseases where knowledge of vasculature status and integrity is of great importance (e.g. atherosclerosis, ischemia). The goal of the proposed program is to develop translational and clinically-relevant imaging technologies that non-invasively can detect and monitor (1) cancer status and (2) predict and monitor the effects of anticancer drugs in a patient-specific manner. This program will further contribute to the fast growing nanotech, cancer therapy and imaging, and medical industries of Ohio. Besides the significant impact on healthcare, this program can potentially facilitate job creation and long-term economic impacts for Ohio. PUBLIC HEALTH RELEVANCE (provided by applicant): Today's cancer therapeutics take a 'one-size-fits-all' approach, and new improved, customizable therapies have to be explored. Via the recruitment of an Assistant Professor, this program aims to integrate nanotechnology with clinically-relevant imaging to provide prognostic and monitoring tools of treatments in a patient-specific manner that enables oncologists to better differentially select therapeutic regimens.