Animal Imaging Core

CF动物成像核心旨在为研究人员提供最先进的设施和 活体成像服务。Core的目标是利用其现有的临床和临床前成像研究 为基础科学家和临床医生提供高效、经济实惠的成像服务的基础设施 囊性纤维化研究。Cf动物成像核心将在结构上扩展，以便 大学中跨部门和跨学院的互动，将研究人员与 体内分析发病、进展、治疗和治疗的基本生理学的共同目的 疾病评估。专用的小动物成像系统的出现允许集成 活体生理测量和显微结构测量以及细胞和遗传测量 慢性萎缩性胃炎动物模型代谢活动的特征。这种方法提供了大量新的 阐明基因中结构、能量和功能之间复杂关系的信息 已被广泛应用于CF研究的操纵动物模型。这些临床前成像 除了成像核心提供的临床成像研究设施外，还具有其他功能 放射科。因此，动物成像核心有效地提供了完整的 提供从基础临床前研究到转化成像研究再到全面临床分析的影像服务 为凯斯西储大学和克利夫兰大学医院的CF中心提供支持。 虽然这个核心被命名为动物成像核心，以区别于细胞成像核心， 请注意，除了高级功能外，还可通过此核心提供人体成像功能 对小鼠和其他动物模型进行成像。

The CF Animal Imaging Core is proposed to provide researchers with the state-of-the-art facilities and services for in vivo imaging. The Core aims to use its existing clinical and preclinical imaging research infrastructure to present efficient and cost-effective imaging services to basic scientists and clinicians for Cystic Fibrosis research. The CF Animal Imaging Core will expand on the structure that facilitates interaction across departments and across schools in the university, bringing together researchers with a shared purpose of in-vivo analysis of underlying physiology of onset, progression, treatment and therapeutic assessment for disease. The advent of dedicated small animal imaging systems allows the integration of in vivo physiologic measurements with microscopic measurements of structure as well as cellular and genetic characterization of metabolic activities in animal models of CF. This approach provides a wealth of new information in elucidating the complex relationship between structure, energetics, and function in genetically manipulated animal models that have been used widely in CF research. These preclinical imaging capabilities are in addition to the clinical imaging research facilities available within Imaging Core / Department of Radiology. Therefore, the Animal Imaging Core efficiently provides the complete range of imaging services from basic preclinical research to translational imaging research to full clinical analysis in support of the CF Center at Case Western Reserve University and University Hospitals of Cleveland. Although this Core has been named the Animal Imaging Core to distinguish it from the Cell Imaging Core, please note that human imaging capabilities are also available through this Core in addition to advanced imaging of mice and other animal models.