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Animal Imaging Core

动物成像核心

基本信息

批准号：
7288643
负责人：
JEFFREY L. DUERK
金额：
$ 14.95万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-05-01 至 2012-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7288643
关键词：
Alveolar Anesthesia procedures Animal Model Animals Anti-Inflammatory Agents Arts Bioluminescence Biomedical Engineering Bone Marrow Transplantation Characteristics Clinical Complex Cystic Fibrosis DNA Data Development Dimensions Disease Disease Progression Doctor of Philosophy Ensure Faculty Fluorescence Future Gelatinase B Gene Transfer Genetic Goals Health Histology Human Image Image Analysis Individual Inflammation Laboratories Longitudinal Studies Lung Magnetic Resonance Imaging Measurement Measures Medicine Metabolic Metabolism Microscopic Modality Modeling Molecular Monitor Mus Names Nuclear Operative Surgical Procedures Optical Coherence Tomography Optics Physiologic Monitoring Physiological Physiology Preparation Procedures Program Development Purpose Radiology Specialty Radionuclide Imaging Range Research Research Infrastructure Research Personnel Resolution Resources Roentgen Rays Safety Schools Scientist Services Small Animal Imaging Systems Spectrum Analysis Standards of Weights and Measures Structure System Therapeutic Time Tissues Universities University Hospitals Work cellular imaging cost flasks in vivo interest liver imaging nanoparticle oncology optical imaging pre-clinical pre-clinical research professor programs research facility research study response single photon emission computed tomography

项目摘要

The CF Animal Imaging Core is proposed to provide researchers with the state-of-the-art facilities and services for in vivo imaging. The Core aims to use its existing clinical and preclinical imaging research infrastructure to present efficient and cost-effective imaging services to basic scientists and clinicians for Cystic Fibrosis research. The CF Animal Imaging Core will expand on the structure that facilitates interaction across departments and across schools in the university, bringing together researchers with a shared purpose of in-vivo analysis of underlying physiology of onset, progression, treatment and therapeutic assessment for disease. The advent of dedicated small animal imaging systems allows the integration of in vivo physiologic measurements with microscopic measurements of structure as well as cellular and genetic characterization of metabolic activities in animal models of CF. This approach provides a wealth of new information in elucidating the complex relationship between structure, energetics, and function in genetically manipulated animal models that have been used widely in CF research. These preclinical imaging capabilities are in addition to the clinical imaging research facilities available within Imaging Core / Department of Radiology. Therefore, the Animal Imaging Core efficiently provides the complete range of imaging services from basic preclinical research to translational imaging research to full clinical analysis in support of the CF Center at Case Western Reserve University and University Hospitals of Cleveland. Although this Core has been named the Animal Imaging Core to distinguish it from the Cell Imaging Core, please note that human imaging capabilities are also available through this Core in addition to advanced imaging of mice and other animal models.

CF动物成像中心旨在为研究人员提供最先进的设施，活体成像服务。核心旨在利用其现有的临床和临床前成像研究基础设施，为基础科学家和临床医生提供高效且具有成本效益的成像服务，囊性纤维化研究。CF Animal Imaging Core将扩展有助于跨部门和跨学校的大学互动，汇集了研究人员与对发病、进展、治疗和治疗的潜在生理学进行体内分析的共同目的评估疾病。专用的小动物成像系统的出现允许将体内生理测量，包括结构以及细胞和遗传的显微测量 CF动物模型中代谢活性的表征。这种方法提供了丰富的新的信息在阐明结构之间的复杂关系，能量学，和功能在遗传操纵的动物模型已被广泛用于CF研究。这些临床前成像除了Imaging Core /中提供的临床成像研究设施之外，还提供其他功能放射科。因此，Animal Imaging Core有效地提供了完整的从基础临床前研究到转化成像研究再到全面临床分析，凯斯西储大学CF中心和克利夫兰大学医院的支持。虽然这个核心被命名为动物成像核心，以区别于细胞成像核心，请注意，除了先进的成像能力之外，小鼠和其他动物模型的成像。