PDAY Cardiovascular Specimen and Data Library

PDAY 心血管样本和数据库

• 批准号: 6926278
• 负责人: JACK P STRONG
• 金额: $ 17.75万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6926278
• 关键词: African American; adolescence (12-20); archives; artery; atherosclerosis; cardiovascular disorder epidemiology; caucasian American; clinical research; coronary disorder; data management; human data; human tissue; tissue resource /registry; young adult human (21-34)

DESCRIPTION (provided by applicant): This project is for the maintenance of the specimen and data base, the PDAY Archive, emanating from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) and Risk Factors in Early Human Atherogenesis (RFEHA) studies so that the Archive can continue to be used effectively by investigators for study of atherosclerosis. PDAY and RFEHA were investigator-initiated multi-center cooperative studies based on a rigidly developed protocol, which had anatomically standardized samples of aorta and coronary arteries of 3,000 young black and white subjects, age 15-34, who died suddenly of trauma. Risk factor data was also obtained in a majority of the cases. So far these studies have yielded over 100 publications. These reports in turn generate a widespread enthusiastic response from investigators throughout the scientific community in the U.S. and abroad. Many investigators are currently utilizing the PDAY specimen and data base as a resource for their studies on atherosclerosis and coronary heart disease. This unique resource, the PDAY Archive, continues to contribute in important ways to our understanding of atherosclerosis, the underlying cause of coronary heart disease and most strokes, which are by far the leading cause of debilitating illnesses and death in this country.

描述（由申请人提供）： 该项目是为了维护样本和数据库，PDAY档案，源于青年动脉粥样硬化的病理生物学决定因素（PDAY）和早期人类动脉粥样硬化发生的危险因素（RFEHA）研究，使档案可以继续有效地使用研究人员对动脉粥样硬化的研究。 PDAY和RFEHA是基于严格制定的方案的由研究者发起的多中心合作研究，其中有3，000名年龄在15-34岁之间的年轻黑人和白色受试者的主动脉和冠状动脉解剖学标准化样本，这些受试者死于创伤。 在大多数病例中也获得了风险因素数据。 到目前为止，这些研究已经产生了100多篇出版物。 这些报告反过来又引起了美国和国外科学界研究人员的广泛热烈反响。 目前，许多研究者正在利用PDAY标本和数据库作为他们研究动脉粥样硬化和冠心病的资源。 这个独特的资源，PDAY档案，继续以重要的方式帮助我们了解动脉粥样硬化，冠心病和大多数中风的根本原因，这是迄今为止导致衰弱疾病和死亡的主要原因。