PDAY CARDIOVASCULAR SPECIMEN AND DATA LIBRARY

描述 （改编自申请人摘要）本项目是为了维护 标本和数据库来自病理学 青年动脉粥样硬化（PDAY）的决定因素和早期危险因素 人类动脉粥样硬化（RFEHA）研究（PDAY Archive），以便可以使用 有效地由研究者继续研究动脉粥样硬化， 未来五年 PDAY和RFEHA均为申办者发起的多中心合作研究 基于严格制定的协议， 3,000名年轻黑人和白色人的主动脉和冠状动脉样本 受试者，年龄15-34岁，因创伤突然死亡。 风险因素数据也 在大多数情况下获得。 到目前为止，这些研究已经产生了超过 PDAY集团的75份出版物。 这些报告反过来又产生了一个 调查人员在整个 科学界在美国和国外。 许多调查人员 目前正在使用或计划使用PDAY档案作为 他们对动脉粥样硬化和冠心病的研究资源。 这个独特的资源，PDAY档案，应该继续作出贡献， 动脉粥样硬化的根本原因， 冠心病（CHD）和大多数中风。 冠心病和中风 是导致这个国家衰弱和死亡的主要原因

DESCRIPTION (Adapted from the applicant's abstract) This project is for the maintenance of the specimen and data base emanating from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) and Risk Factors in Early Human Atherogenesis (RFEHA) studies (PDAY Archive) so that it can be used effectively by investigators for continued study of atherosclerosis during the next five years. PDAY and RFEHA were investigator-initiated multi-center cooperative studies based on a rigidly developed protocol, which had anatomically standardized samples of aorta and coronary arteries of 3,000 young black and white subjects, age 15-34, who died suddenly of trauma. Risk factor data was also obtained in a majority of the cases. So far these studies have yielded over 75 publications by the PDAY group. These reports in turn have generated a widespread enthusiastic response from investigators throughout the scientific community in the U.S. and abroad. Many of these investigators are currently utilizing or planning to utilize the PDAY Archive as a resource for their studies on atherosclerosis and coronary heart disease. This unique resource, the PDAY Archive, should continue to contribute in important ways to our understanding of atherosclerosis, the underlying cause of coronary heart disease (CHD) and most strokes. CHD and stroke are by far the leading cause of debilitating illnesses and death in this country.