PDAY CARDIOVASCULAR SPECIMEN AND DATA LIBRARY

PDAY 心血管样本和数据库

• 批准号: 6527175
• 负责人: JACK P STRONG
• 金额: $ 13.19万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6527175
• 关键词: adolescence (12-20); aorta; archives; atherosclerosis; cardiovascular disorder epidemiology; clinical research; coronary artery; coronary disorder; data management; disease /disorder proneness /risk; human data; tissue resource /registry; young adult human (21-34)

DESCRIPTION (Adapted from the applicant's abstract) This project is for the maintenance of the specimen and data base emanating from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) and Risk Factors in Early Human Atherogenesis (RFEHA) studies (PDAY Archive) so that it can be used effectively by investigators for continued study of atherosclerosis during the next five years. PDAY and RFEHA were investigator-initiated multi-center cooperative studies based on a rigidly developed protocol, which had anatomically standardized samples of aorta and coronary arteries of 3,000 young black and white subjects, age 15-34, who died suddenly of trauma. Risk factor data was also obtained in a majority of the cases. So far these studies have yielded over 75 publications by the PDAY group. These reports in turn have generated a widespread enthusiastic response from investigators throughout the scientific community in the U.S. and abroad. Many of these investigators are currently utilizing or planning to utilize the PDAY Archive as a resource for their studies on atherosclerosis and coronary heart disease. This unique resource, the PDAY Archive, should continue to contribute in important ways to our understanding of atherosclerosis, the underlying cause of coronary heart disease (CHD) and most strokes. CHD and stroke are by far the leading cause of debilitating illnesses and death in this country.

描述 (改编自申请人的摘要)本项目用于维护 来自病理生物学的标本和数据库 青年动脉粥样硬化(PDAY)决定因素及早期危险因素 人类动脉粥样硬化(RFEHA)研究(PDAY档案)，以便可以使用 被研究人员有效地用于动脉粥样硬化的持续研究 接下来的五年。 PDAY和RFEHA是由研究者发起的多中心合作研究 基于严格开发的协议，该协议在解剖学上已标准化 3000名青年黑人和白人的主动脉和冠状动脉标本 受试者，年龄15-34岁，突然死于创伤。风险因素数据也是 在大多数案件中都获得了。到目前为止，这些研究已经取得了成果 由PDAY集团出版的75种出版物。这些报告反过来又生成了 全国各地调查人员普遍反应热烈 美国和国外的科学界。许多这样的调查人员 目前正在使用或计划将PDAY档案用作 为他们研究动脉粥样硬化和冠心病提供资源。 这一独特的资源，即PDAY档案，应该继续在 了解动脉粥样硬化的重要途径 冠心病(CHD)和大多数中风的风险。到目前为止，冠心病和中风 这是这个国家导致虚弱疾病和死亡的主要原因。