PDAY Cardiovascular Specimen and Data Library

描述(申请人提供)：本项目是为了维护样本和数据库，PDAY档案，源自青年动脉粥样硬化的病理生物学决定因素(PDAY)和早期人类动脉粥样硬化(RFEHA)研究中的风险因素，以便研究人员能够继续有效地利用该档案进行动脉粥样硬化研究。 PDAY和RFEHA是研究人员发起的多中心合作研究，基于严格制定的方案，该方案拥有3000名年龄在15-34岁之间的年轻黑人和白人突然死于创伤的主动脉和冠状动脉的解剖学标准化样本。在大多数情况下，还获得了风险因素数据。到目前为止，这些研究已经发表了100多篇论文。这些报告反过来又在美国和国外的科学界引起了调查人员的广泛热情反应。许多研究人员目前正在利用PDAY标本和数据库作为他们研究动脉粥样硬化和冠心病的资源。这个独特的资源，PDAY档案，继续以重要的方式帮助我们了解动脉粥样硬化，动脉粥样硬化是冠心病和大多数中风的根本原因，到目前为止，这是这个国家导致衰弱疾病和死亡的主要原因。

DESCRIPTION (provided by applicant): This project is for the maintenance of the specimen and data base, the PDAY Archive, emanating from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) and Risk Factors in Early Human Atherogenesis (RFEHA) studies so that the Archive can continue to be used effectively by investigators for study of atherosclerosis. PDAY and RFEHA were investigator-initiated multi-center cooperative studies based on a rigidly developed protocol, which had anatomically standardized samples of aorta and coronary arteries of 3,000 young black and white subjects, age 15-34, who died suddenly of trauma. Risk factor data was also obtained in a majority of the cases. So far these studies have yielded over 100 publications. These reports in turn generate a widespread enthusiastic response from investigators throughout the scientific community in the U.S. and abroad. Many investigators are currently utilizing the PDAY specimen and data base as a resource for their studies on atherosclerosis and coronary heart disease. This unique resource, the PDAY Archive, continues to contribute in important ways to our understanding of atherosclerosis, the underlying cause of coronary heart disease and most strokes, which are by far the leading cause of debilitating illnesses and death in this country.