Cardiac MRI with 3D Undersampled Radial Imaging

描述（由候选人提供）： 本提案的目的是为申请人Dana Peters提供一种方法，使其成为使用径向采集方法的心血管MR领域的独立科学家和领导者。该提案为她提供了两名导师，一名心脏病专家因其MR贡献而获得认可，一名MR物理学家因其在心血管研究方面的工作而获得认可，并得到了Beth Israel Deaconess Medical Center心脏病学部门的支持。职业发展计划描述了一条实现成为心血管MR领导者目标的道路，重点关注图像处理，心血管医学和统计学领域。到目前为止，她的重点一直是欠采样径向成像的快速和高分辨率的应用。该研究提案详细介绍了用于心脏功能和存活力的欠采样3D径向（x-y平面中的切片编码和投影）序列的开发。这项工作的重点是这种方法在患者群体中的开发、改进和验证。3D方法的价值在于其完全覆盖心脏，例如在压力测试期间，与2D方法的10次屏气相比，其在单次屏气中完成，以及与2D相比，3D的潜在更高SNR。首先，将改进基本的心电门控分段3D径向方法，以消除径向采集造成的伪影，特别是在存在非共振、血流和SSFP对比度的情况下。然后，新开发的欠采样伪影减少技术将用于提高图像质量的高度欠采样的方法。呼吸门控 还将研究成像。对于心肌功能，将比较3D方法与2D方法 验证左心室质量、体积和局部室壁增厚值的方法。将开发T1加权单相活力序列。发展将集中在增加空间分辨率，提高梗死和远端心肌之间的对比度，并减少信号再生的伪影。 高分辨率3D放射状活力技术将在动物中进行验证，也可用于患者。

DESCRIPTION (provided by candidate): The purpose of this proposal is to provide a means for the applicant, Dana Peters, to develop as an independent scientist and leader in cardiovascular MR using the radial acquisition method. This proposal provides her with two mentors, a cardiologist recognized for his MR contributions, and a MR physicist for his work in cardiovascular research, and support from the Cardiology Division of Beth Israel Deaconess Medical Center. The career development plan describes a path by which to obtain the goal of becoming a leader in cardiovascular MR, focusing in the areas of image processing, cardiovascular medicine, and statistics. To date, her focus has been on undersampled radial imaging for fast and high-resolution applications. The research proposal details the development of an undersampled 3D radial (slice-encodings and projections in x-y plane) sequence for cardiac function and viability. This work focuses on the development, refinement, and validation in patient populations of this method. The value of the 3D method is its complete coverage of the heart, for example during a stress test, its completion in a single breath-hold compared to 10 breath holds for the 2D approach, and potentially higher SNR of 3D compared with 2D. First the basic ecg-gated segmented 3D radial method will be refined to remove artifacts due to the radial acquisition, especially in the presence of off-resonance, flow, and SSFP contrast. Then newly developed undersampling artifact reduction techniques will be used to improve image quality of highly undersampled methods. Respiratory gated imaging will also be investigated. For myocardial function, 3D methods will be compared to 2D methods to validate left ventricular mass, volumes, and regional wall thickening values. A T1-weighted single phase viability sequence will be developed. Development will focus on increasing spatial resolution, improving contrast between infarcted and remote myocardium, and reducing artifacts from signal regrowth. The high resolution 3D radial viability technique will be validated in animals, and also used in patients.