Cardiac MRI with 3D Undersampled Radial Imaging

描述(由候选人提供)： 这项提议的目的是为申请者Dana Peters提供一种手段，使其成为一名独立的科学家和心血管磁共振领域的领导者，使用径向采集方法。这项提议为她提供了两位导师，一位因其MR贡献而受到认可的心脏病专家，一位因其在心血管研究方面的工作而受到认可的MR物理学家，以及贝丝以色列女执事医疗中心心脏病科的支持。职业发展计划描述了一条实现成为心血管磁共振领导者的目标的途径，重点放在图像处理、心血管医学和统计学领域。到目前为止，她一直专注于用于快速和高分辨率应用的欠采样径向成像。该研究提案详细说明了用于心脏功能和生存能力的欠采样3D径向(切片编码和x-y平面投影)序列的开发。这项工作的重点是这种方法的开发、改进和在患者群体中的验证。3D方法的价值在于它对心脏的完整覆盖，例如在压力测试期间，与2D方法的10次屏气相比，它在一次屏气中完成，并且与2D方法相比，3D方法的潜在SNR更高。首先，对基本的心电门控分段3D径向方法进行改进，以消除由于径向采集引起的伪影，特别是在存在非共振、流动和SSFP对比度的情况下。然后，使用新开发的欠采样伪影抑制技术来改善高欠采样方法的图像质量。呼吸门控 成像也将被调查。对于心肌功能，3D方法将与2D方法进行比较 方法验证左心室质量、容量和节段性室壁增厚值。将开发一个T1加权的单相生存序列。开发的重点将是提高空间分辨率，改善梗死心肌和远程心肌之间的对比度，并减少信号再生带来的伪影。高分辨率3D放射状存活技术将在动物身上得到验证，也将在患者中使用。

DESCRIPTION (provided by candidate): The purpose of this proposal is to provide a means for the applicant, Dana Peters, to develop as an independent scientist and leader in cardiovascular MR using the radial acquisition method. This proposal provides her with two mentors, a cardiologist recognized for his MR contributions, and a MR physicist for his work in cardiovascular research, and support from the Cardiology Division of Beth Israel Deaconess Medical Center. The career development plan describes a path by which to obtain the goal of becoming a leader in cardiovascular MR, focusing in the areas of image processing, cardiovascular medicine, and statistics. To date, her focus has been on undersampled radial imaging for fast and high-resolution applications. The research proposal details the development of an undersampled 3D radial (slice-encodings and projections in x-y plane) sequence for cardiac function and viability. This work focuses on the development, refinement, and validation in patient populations of this method. The value of the 3D method is its complete coverage of the heart, for example during a stress test, its completion in a single breath-hold compared to 10 breath holds for the 2D approach, and potentially higher SNR of 3D compared with 2D. First the basic ecg-gated segmented 3D radial method will be refined to remove artifacts due to the radial acquisition, especially in the presence of off-resonance, flow, and SSFP contrast. Then newly developed undersampling artifact reduction techniques will be used to improve image quality of highly undersampled methods. Respiratory gated imaging will also be investigated. For myocardial function, 3D methods will be compared to 2D methods to validate left ventricular mass, volumes, and regional wall thickening values. A T1-weighted single phase viability sequence will be developed. Development will focus on increasing spatial resolution, improving contrast between infarcted and remote myocardium, and reducing artifacts from signal regrowth. The high resolution 3D radial viability technique will be validated in animals, and also used in patients.