Cardiac MRI with 3D Undersampled Radial Imaging

具有 3D 欠采样径向成像的心脏 MRI

• 批准号: 7105542
• 负责人: DANA C PETERS
• 金额: $ 10.16万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7105542
• 关键词: bioimaging /biomedical imaging; cardiography; clinical research; human subject; image processing; magnetic resonance imaging; miniature swine; myocardial infarct sizing; myocardial infarction; patient oriented research; swine; three dimensional imaging /topography

DESCRIPTION (provided by candidate): The purpose of this proposal is to provide a means for the applicant, Dana Peters, to develop as an independent scientist and leader in cardiovascular MR using the radial acquisition method. This proposal provides her with two mentors, a cardiologist recognized for his MR contributions, and a MR physicist for his work in cardiovascular research, and support from the Cardiology Division of Beth Israel Deaconess Medical Center. The career development plan describes a path by which to obtain the goal of becoming a leader in cardiovascular MR, focusing in the areas of image processing, cardiovascular medicine, and statistics. To date, her focus has been on undersampled radial imaging for fast and high-resolution applications. The research proposal details the development of an undersampled 3D radial (slice-encodings and projections in x-y plane) sequence for cardiac function and viability. This work focuses on the development, refinement, and validation in patient populations of this method. The value of the 3D method is its complete coverage of the heart, for example during a stress test, its completion in a single breath-hold compared to 10 breath holds for the 2D approach, and potentially higher SNR of 3D compared with 2D. First the basic ecg-gated segmented 3D radial method will be refined to remove artifacts due to the radial acquisition, especially in the presence of off-resonance, flow, and SSFP contrast. Then newly developed undersampling artifact reduction techniques will be used to improve image quality of highly undersampled methods. Respiratory gated imaging will also be investigated. For myocardial function, 3D methods will be compared to 2D methods to validate left ventricular mass, volumes, and regional wall thickening values. A T1-weighted single phase viability sequence will be developed. Development will focus on increasing spatial resolution, improving contrast between infarcted and remote myocardium, and reducing artifacts from signal regrowth. The high resolution 3D radial viability technique will be validated in animals, and also used in patients.

描述（由候选人提供）： 该提案的目的是为申请人 Dana Peters 提供一种方法，使其成为使用径向采集方法的心血管 MR 领域的独立科学家和领导者。该提案为她提供了两名导师，一名因 MR 贡献而受到认可的心脏病专家，以及一名因心血管研究工作而受到认可的 MR 物理学家，以及贝斯以色列女执事医疗中心心脏病科的支持。职业发展规划描述了实现成为心血管MR领域领导者目标的路径，重点关注图像处理、心血管医学和统计学领域。迄今为止，她的重点一直是用于快速和高分辨率应用的欠采样径向成像。该研究提案详细介绍了用于心脏功能和活力的欠采样 3D 径向（x-y 平面中的切片编码和投影）序列的开发。这项工作的重点是该方法的开发、完善和在患者群体中的验证。 3D 方法的价值在于它完全覆盖心脏，例如在压力测试期间，与 2D 方法的 10 次屏气相比，它在一次屏气中完成，并且与 2D 相比，3D 的 SNR 可能更高。首先，将对基本心电门控分段 3D 径向方法进行改进，以消除由于径向采集而产生的伪影，特别是在存在失共振、血流和 SSFP 对比度的情况下。然后，新开发的欠采样伪影减少技术将用于提高高度欠采样方法的图像质量。呼吸门控 成像也将被研究。对于心肌功能，3D 方法将与 2D 方法进行比较 验证左心室质量、体积和局部室壁增厚值的方法。将开发 T1 加权单相生存序列。开发将集中于提高空间分辨率、改善梗塞心肌和远端心肌之间的对比度以及减少信号再生造成的伪影。 高分辨率 3D 径向活力技术将在动物身上进行验证，也可用于患者。