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How Deletional and Non-Deletional Tolerance Mechanisms Integrate to Prevent Autoimmune Disease

How Deletional and Non-Deletional Tolerance Mechanisms Integrate to Prevent Autoimmune Disease
缺失和非缺失耐受机制如何整合以预防自身免疫性疾病
批准号：
nhmrc : 1049724
负责人：
A/Pr Daniel Gray
金额：
$34.0万
依托单位：
The Walter and Eliza Hall Institute of Medical Research
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2013
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2013-01-01 至 2015-12-31
来源：
https://researchdata.edu.au/deletional-non-deletional-autoimmune-disease/112108
关键词：
HowDeletionalNonToleranceMechanisms

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中文摘要
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英文摘要
The body produces millions of immune cells every day to fight infection. Some of these immune cells are defective and dangerous because they can cause autoimmune diseases, like Type I diabetes and multiple sclerosis. To defuse this risk, such immune cells are either caused to die or are inactivated to prevent autoimmunity. We propose to investigate how the processes of immune cell death and inactivation work in health and disease so we may harness these mechanisms to cure autoimmunity.
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会议论文
Targeting Cell Death Pathways in Immune Pathology and Cancer
  • 批准号：
    nhmrc : GNT1158024
  • 项目类别：
    Research Fellowships
  • 资助金额：
    $64.92万
  • 财政年份：
    2019
  • 负责人：
    A/Pr Daniel Gray
  • 依托单位：
Targeting Caspase 8 in T-Cell Homeostasis and Disease
  • 批准号：
    nhmrc : GNT1145888
  • 项目类别：
    Project Grants
  • 资助金额：
    $121.58万
  • 财政年份：
    2018
  • 负责人：
    A/Pr Daniel Gray
  • 依托单位：
Targeting Caspase 8 in T-Cell Homeostasis and Disease
The Mechanisms of Epithelial Cell Survival that Govern Thymus Function
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