Understanding the pathogenesis and heterogeneity of autoimmunity as failure of multiple steps

了解自身免疫的发病机制和异质性作为多个步骤的失败

• 批准号: nhmrc : 1009190
• 负责人: A/Pr Daniel Gray
• 金额: $ 33.61万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-pathogenesis-heterogeneity-multiple-steps/109381
• 关键词: Understanding; pathogenesis; heterogeneity; autoimmunity; failure

Autoimmune diseases like diabetes, thyroid disease or rheumatoid arthritis affect around 1 in 15 people in Australia. It is clear that defects in a number of different genetic mechanisms can contribute to the development of autoimmunity. But it is currently not clear how these different mechanisms need to interact to prevent the onset of disease. This grant seeks to understand these interactions and how defects in two or more tolerance mechanisms can lead to autoimmunity.

在澳大利亚，糖尿病、甲状腺疾病或类风湿性关节炎等自身免疫性疾病影响着大约1/15的人。很明显，许多不同遗传机制的缺陷可能有助于自身免疫的发展。但目前尚不清楚这些不同的机制需要如何相互作用以预防疾病的发生。该基金旨在了解这些相互作用以及两种或多种耐受机制的缺陷如何导致自身免疫。